Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes
Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes
复制标题
益气补肾方提取物对糖尿病大鼠脑干听觉诱发电位的影响。
DOI：
10.1016/j.jep.2011.05.033
复制
发表时间：
2011-09-01
影响因子：
5.4
通讯作者：
Takayanagi, Ryoichi
中科院分区：
文献类型：
--
作者：
Liu, De-shan;Gao, Wei;Takayanagi, Ryoichi
本研究旨在探讨益气补肾方对糖尿病大鼠脑干听觉诱发电位（BAEP）的影响及对糖尿病大鼠脑功能损害的保护作用。将33只雄性大鼠随机分为正常对照组（NC）、糖尿病组（DM）和糖尿病+YB组（DM + YB）。每三周测量一次血糖和体重。6周后测定血清胰岛素、血生化指标、超氧化物歧化酶、丙二醛、单胺类神经递质及脑干听觉诱发电位。与NC组比较，DM组BAEP的III、VPLs和I-III、I-VIPL均明显延迟（P均< 0.05）。然而，YB治疗的糖尿病大鼠在实验期间保持正常的脑干功能。与NC组比较，DM + YB组BAEP的I、III、VPL波和I-III、III-V、I-VIPL波非常接近（均P > 0.05）。与DM组比较，DM + YB组BAEP的III、VPLs和I-III、I-VIPL均明显改善。发现糖尿病大鼠中枢传导时间与血清胰岛素、血糖、丙二醛及胰岛素抵抗指数密切相关。我们的研究结果表明，YB提取物在保护糖尿病大鼠大脑的电生理功能方面具有有益的作用，可能是通过其抗高血糖活性，降低胰岛素抵抗的能力和抗氧化活性。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
This study was designed to investigate the effects of the Chinese Yi-Qi-Bu-Shen Recipe (YB) on brain stem auditory evoked potential (BAEP) in diabetic rats and on the protection of the diabetic rat brain's functional lesion. Thirty-three male rats were randomly divided into three groups: the normal control group (NC), the diabetic group (DM), and the diabetic rats treated with YB group (DM + YB). Blood glucose and body weight were measured every three weeks. After six weeks, the serum insulin, blood biochemical indices, superoxide dismutase, malondialdehyde, monoamine neurotransmitters, and BAEP were measured. Compared with the NC group, the waves III, V PLs, and the I-III, I-V IPLs of BAEP in the DM group were significantly delayed (all P < 0.05). However, YB-treated diabetic rats maintained a normal brainstem function over the experimental period. Compared with the NC group, the waves I, III, V PL, and waves I-III, III-V and I-V IPLs of BAEP in the DM + YB group were very close (all P > 0.05). On the other hand, compared with the DM group, the III, V PLs and the I-III,I-V IPLs of BAEP in the DM + YB group were significantly improved. It was discovered that the central conduction time of rats with diabetes had a close correlation with serum insulin, blood glucose, malondialdehyde, and insulin resistance index. Our results suggest that YB extract has a beneficial effect in preserving the brain's electrophysiological function in diabetic rats, likely through its antihyperglycemic activity, ability to reduce insulin resistance, and antioxidant activity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.