Ketamine Treatment and Global Brain Connectivity in Major Depression
Ketamine Treatment and Global Brain Connectivity in Major Depression
复制标题
DOI：
10.1038/npp.2016.186
复制
发表时间：
2017-05-01
影响因子：
7.6
通讯作者：
Murrough, James W.
中科院分区：
文献类型：
--
作者：
Abdallah, Chadi G.;Averill, Lynnette A.;Murrough, James W.
利用静息态功能连接磁共振成像（rs-fcMRI）的最新进展和氯胺酮治疗后快速情绪正常化的独特范例，本研究调查了抑郁发作期间和氯胺酮治疗后重度抑郁症（MDD）的内在脑网络。无药物治疗的MDD患者和健康对照受试者（HC）完成了基线rs-fcMRI。MDD患者接受单次氯胺酮输注，并在治疗后24 h进行重复rs-fcMRI。具有全局信号回归（GBCr）值的全局脑连接性被计算为每个体素与脑中所有其他灰质体素的相关性的平均值。MDD组前额叶皮质GBCr降低，扣带回后部、楔前叶、舌回和小脑GBCr升高。氯胺酮显著增加PFC中的GBCr，降低小脑中的GBCr。在基线时，确定了2174个改变的GBCr体素，但治疗后相对于对照组只有310个体素显著不同（校正α
Capitalizing on recent advances in resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) and the distinctive paradigm of rapid mood normalization following ketamine treatment, the current study investigated intrinsic brain networks in major depressive disorder (MDD) during a depressive episode and following treatment with ketamine. Medication-free patients with MDD and healthy control subjects (HC) completed baseline rs-fcMRI. MDD patients received a single infusion of ketamine and underwent repeated rs-fcMRI at 24 h posttreatment. Global brain connectivity with global signal regression (GBCr) values were computed as the average of correlations of each voxel with all other gray matter voxels in the brain. MDD group showed reduced GBCr in the prefrontal cortex (PFC) but increased GBCr in the posterior cingulate, precuneus, lingual gyrus, and cerebellum. Ketamine significantly increased GBCr in the PFC and reduced GBCr in the cerebellum. At baseline, 2174 voxels of altered GBCr were identified, but only 310 voxels significantly differed relative to controls following treatment (corrected alpha