Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma
Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma
复制标题
原发性开角型青光眼视觉和高阶认知皮质脑血流和功能连接强度的耦合改变
DOI：
10.1177/0271678x20935274
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发表时间：
2020-06-24
影响因子：
6.3
通讯作者：
Xian, Junfang
中科院分区：
文献类型：
--
作者：
Wang, Qian;Qu, Xiaoxia;Xian, Junfang
原发性开角型青光眼（POAG）被认为是一种神经退行性疾病，与脑血管血流动力学改变以及视觉、工作记忆、注意力和执行网络内神经元活动的广泛紊乱有关。我们假设POAG患者存在视觉和高级认知皮层的神经血管耦合紊乱，且与青光眼分期和视野缺损相关。通过多模态磁共振成像，我们评估了所有受试者全脑灰质的脑血流（CBF）-功能连接强度（FCS）相关性以及每个体素的CBF/FCS比值。与正常对照组相比，POAG患者表现出整体CBF - FCS耦合降低以及CBF/FCS比值改变，主要发生在视觉皮层、突显网络、默认模式网络和背侧注意网络区域。在POAG患者中，CBF/FCS比值与青光眼分期呈负相关，与舌回的视野缺损呈正相关。此外，在早期POAG中检测到了脑部的早期变化。这些发现表明POAG患者的视觉和高级认知皮层可能存在神经血管耦合功能障碍及其临床相关性。研究结果可能有助于监测POAG的进展，并为了解POAG神经退行性过程的病理生理学提供依据。
Primary open-angle glaucoma (POAG) has been suggested to be a neurodegenerative disease associated with altered cerebral vascular hemodynamics and widespread disruption of neuronal activity within the visual, working memory, attention and executive networks. We hypothesized that disturbed neurovascular coupling in visual and higher order cognitive cortices exists in POAG patients and correlates with glaucoma stage and visual field defects. Through multimodal magnetic resonance imaging, we evaluated the cerebral blood flow (CBF)-functional connectivity strength (FCS) correlations of the whole gray matter and CBF/FCS ratio per voxel for all subjects. Compared with normal controls, POAG patients showed reduced global CBF-FCS coupling and altered CBF/FCS ratios, predominantly in regions in the visual cortex, salience network, default mode network, and dorsal attentional network. The CBF/FCS ratio was negatively correlated with glaucoma stage, and positively correlated with visual field defects in the lingual gyrus in POAG patients. Moreover, early brain changes were detected in early POAG. These findings indicate neurovascular coupling dysfunction might exist in the visual and higher order cognitive cortices in POAG patients and its clinical relevance. The results may contribute to the monitoring of POAG progression and provide insight into the pathophysiology of the neurodegenerative process in POAG.