The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: An exploratory study
The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: An exploratory study
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DOI：
10.1097/00006842-199801000-00003
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Kotler, DP
中科院分区：
文献类型：
--
作者：
Goggin, K;Engelson, ES;Kotler, DP
目的：这项探索性研究评估了HIV阳性女性的情绪障碍、性障碍和内分泌异常的患病率，并探讨了这些参数之间的关系。方法：采用DSM-III-R结构化临床访谈(SCID)和精神症状严重度、心理幸福感及性问题量表对54例HIV阳性妇女进行测评。妇女还提供血液以确定CD4细胞计数、血清总睾酮和脱氢表雄酮硫酸盐(DHEAS)水平。结果：虽然目前Axis I诊断的总体水平较低，但39%的女性被诊断为性欲减退(HSDD)。48%的样本睾酮水平不足(低于20.0 ng/dl)，27%的样本DHEAS水平不足(低于35.0微克/dl)。我们发现性欲减弱与睾酮、脱氢表雄酮或情绪障碍诊断水平不足之间没有显著关系。然而，HSDD与更多的抑郁症状和更低的生活满意度显著相关。认为HIV感染的危险因素包括性接触的妇女被诊断为新发HSDD的可能性是报告将静脉吸毒(IVDU)作为唯一危险因素的妇女的五倍以上(分别为47%和9%)。结论：我们观察到HSDD和内分泌异常的发生率似乎很高，而情绪障碍的发生率非常低。有趣的是，内分泌异常与性欲低下无关。我们的发现表明，在城市HIV+女性中，对性欲减退障碍的治疗存在着显著的未得到满足的需求。
Objective: This exploratory study assessed the prevalence of mood disorders, sexual disorders, and endocrine abnormalities, and explored the relationship between these parameters in a sample of HIV+ women. Method: Fifty-four HIV+ women were evaluated with the Structured Clinical Interview for DSM-III-R (SCID) and measures of psychiatric symptom severity, psychological well-being, and sexual problems. Women also provided blood to establish CD4 cell count, serum total testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels. Results: Although overall levels of current Axis I diagnosis were low, Hypoactive Sexual Desire Disorder (HSDD) was diagnosed in 39% of the women. Forty-eight percent of the sample had deficient testosterone levels (below 20.0 ng/dl) and 27% had deficient DHEAS levels (below 35.0 mu g/dl). We found no significant relationship between diminished sexual desire and deficient levels of testosterone, DHEAS, or mood disorder diagnoses. However, HSDD was significantly related to more depressive symptoms and lower life satisfaction. Women whose perceived risk factor for HIV infection included sexual contact were more than five times more likely to be diagnosed with a new onset HSDD than women who reported intravenous drug use (IVDU) as their only risk factor (47% vs. 9%, respectively). Conclusions: We observed what seems to be high rates of HSDD and endocrine abnormalities with very low rates of mood disorders. Interestingly, endocrine abnormalities were not associated with low sexual desire. Our findings suggest that there is a significant unmet need for treatment of Hypoactive Sexual Desire Disorder among urban HIV+ women.