Angiogenesis in the ovary.
Angiogenesis in the ovary.
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DOI：
10.1530/ror.0.0010182
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发表时间：
1996-09
期刊：
影响因子：
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通讯作者：
D. Redmer;L. Reynolds
中科院分区：
文献类型：
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作者：
D. Redmer;L. Reynolds
在成人组织中，毛细血管生长（血管生成）通常发生在组织修复期间，例如在伤口和骨折的愈合中。不适当的毛细血管生长与各种病理状况相关，包括毛细血管生长猖獗的情况下的肿瘤生长、视网膜病、血管瘤、纤维化和类风湿性关节炎，以及毛细血管生长不足的情况下的不愈合伤口和骨折。女性生殖器官表现出明显的、周期性的生长和退化，同时伴随着它们的血流速度同样惊人的变化。因此，这并不奇怪，它们是少数几个成人组织中血管生成作为一个正常过程发生的一些。卵巢卵泡和黄体已被证明含有并产生血管生成因子。这些血管生成因子似乎是肝素结合的，并且属于成纤维细胞生长因子（FGF）和血管内皮生长因子（VEGF）蛋白质家族。此外，调节缝隙连接通讯的因素可能在协调黄体血管和非血管组织之间的相互作用中发挥关键作用。进一步阐明这些因子在卵泡和黄体生长、发育和功能中的特定生理作用将最终导致调节哺乳动物生育力的改进方法。
In adult tissues, capillary growth (angiogenesis) occurs normally during tissue repair, such as in the healing of wounds and fractures. Inappropriate capillary growth is associated with various pathological conditions, including tumour growth, retinopathies, haemangiomas, fibroses and rheumatoid arthritis in the case of rampant capillary growth, and nonhealing wounds and fractures in the case of inadequate capillary growth. The female reproductive organs exhibit marked, periodic growth and regression, accompanied by equally striking changes in their rates of blood flow. It is not surprising, therefore, that they are some of the few adult tissues in which angiogenesis occurs as a normal process. Ovarian follicles and corpora lutea have been shown to contain and produce angiogenic factors. These angiogenic factors appear to be heparin-binding and to belong to the fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) families of proteins. In addition, factors regulating gap junctional communication may play a critical role in coordinating the interactions between luteal vascular and nonvascular tissues. Further elucidation of the specific physiological roles of these factors in follicular and luteal growth, development and function will ultimately lead to improved methods for regulating fertility in mammals.