Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds
Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds
复制标题
DOI：
10.1016/j.carbpol.2017.01.061
复制
发表时间：
2017-05-15
影响因子：
11.2
通讯作者：
Wahid, Fazli
中科院分区：
文献类型：
--
作者：
Khalid, Ayesha;Khan, Romana;Wahid, Fazli
细菌纤维素具有理想的创面敷料材料的物理机械性能，但缺乏抗菌活性限制了其在生物医学上的应用。因此，在目前的研究中，将细菌纤维素固有的伤口愈合特性与纳米氧化锌的抗菌性能相结合。通过各种表征技术证实了氧化锌纳米颗粒对细菌纤维素片的增强(浸渍)作用。测试了细菌纤维素-氧化锌纳米复合材料对常见烧伤病原菌的抑菌能力。在BALB(C)小鼠烧伤模型上观察了纳米复合材料的体内创面愈合和组织再生情况。表征技术证实了纳米颗粒成功地浸渍到细菌纤维素中。细菌纤维素-氧化锌纳米复合材料对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和弗氏柠檬酸杆菌的抑制率分别为90%、87.4%、94.3%和90.9%。细菌纤维素-氧化锌纳米复合材料治疗的动物显示出显著的愈合活性(66%)。组织学检查显示，复合体处理组组织再生良好。这些发现表明细菌纤维素-氧化锌纳米复合材料可能是一种新型的烧伤敷料材料。(C)2017爱思唯尔有限公司。保留所有权利。
Bacterial cellulose possesses physical and mechanical properties of an ideal wound dressing material but lack of antimicrobial activity limits its biomedical applications. Therefore, in current study, the inherent wound healing characteristics of bacterial cellulose and antimicrobial properties of zinc oxide nanoparticles were combined. The reinforcement (impregnation) of zinc oxide nanoparticles into bacterial cellulose sheets was confirmed through various characterization techniques. The antimicrobial capacity of bacterial cellulose-zinc oxide nanocomposites was tested against common burn pathogens. The in-vivo wound healing and tissue regeneration of the nanocomposites was investigated in burn BALB(C) mice model. Characterization techniques confirmed the successful impregnation of nanoparticles into bacterial cellulose. Bacterial cellulose-zinc oxide nanocomposites exhibited 90%, 87.4%, 94.3% and 90.9% activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Citrobacter freundii, respectively. Bacterial cellulose-zinc oxide nanocomposites treated animals showed significant (66%) healing activity. The histological analysis revealed fine tissue regeneration in composites treated group. These findings suggest that bacterial cellulose-zinc oxide nanocomposites could be a novel dressing material for burns. (C) 2017 Elsevier Ltd. All rights reserved.