Regulation of inflammation-related genes in human adipose tissue
Regulation of inflammation-related genes in human adipose tissue
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DOI：
10.1111/j.1365-2796.2007.01851.x
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发表时间：
2007-10-01
影响因子：
11.1
通讯作者：
Langin, D.
中科院分区：
文献类型：
--
作者：
Clement, K.;Langin, D.
肥胖者循环中炎症因子的适度增加，脂肪组织炎症基因表达变化的描述，以及巨噬细胞渗入脂肪组织的发现，这些观察结果有助于提出人类肥胖是一种慢性炎症性疾病的概念。这一概念导致了对肥胖症的生理病理学及其相关代谢和心血管并发症的一些修订。AT中的低级别炎症和随后产生的特定生物标记物实际上可能将肥胖症并发症与肥胖症联系起来。这篇综述旨在提供人类基因表达研究带来的最新知识的概述，特别是那些在AT仓库进行的大规模研究。在基于卡路里限制和体育锻炼的减肥计划的背景下，讨论了与炎症和假定的新候选者(即组织蛋白和血清淀粉样蛋白A)相关的特定生物标志物的调节。还总结了可预见的临床和技术挑战。
The identification of a moderate increase in circulating inflammatory factors in obese subjects, the description of changes in inflammatory gene expression in adipose tissue (AT) and the discovery that macrophage cells infiltrate AT are observations contributing to the concept that human obesity is a chronic inflammatory illness. This concept has led to some revision of the physiopathology of obesity and of its related metabolic and cardiovascular co-morbidities. Low-grade inflammation in the AT and the subsequent production of specific biomarkers could actually link expanded fat mass to obesity complications. This review aims at providing an overview of the current knowledge brought up by human gene expression studies, notably those performed on a large scale in AT depots. The regulation of specific biomarkers related to inflammation and putative new candidates (i.e. cathepsins and serum amyloid A) is discussed in the context of weight loss programmes based on calorie restriction and physical exercise. The foreseen clinical and technological challenges are also summarized.