The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia
The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia
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DOI：
10.1016/j.jcv.2013.11.004
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发表时间：
2014-01-01
影响因子：
8.8
通讯作者：
Slama, Jiri
中科院分区：
文献类型：
--
作者：
Sehnal, Borek;Dusek, Ladislav;Slama, Jiri
背景资料：超过90%的肛门癌病例是由高危型人乳头瘤病毒（HR HPV）感染引起的，宫颈上皮内瘤变（CIN）的病史被认为是可能的危险因素。Objective.Objectives：To证明肛门和宫颈HPV感染与不同级别的CIN和微侵袭性宫颈癌之间的关系。研究组包括172名因高度CIN或微浸润性宫颈癌接受锥切术的妇女。对照组由100名患有非肿瘤性妇科疾病或活检证实的CIN 1的妇女组成。所有参与者都完成了一份问卷，详细描述了他们的病史和性风险因素，并使用Cobas和Lynear阵列HPV检测进行了肛门和宫颈HPV基因分型。在研究组中，82.6%、48.3%和42.4%的妇女检测到宫颈、肛门以及同时发生宫颈和肛门HPV感染，28.0%的妇女，对照组分别为26.0%和8.0%。高危型HPV感染率在研究组中较高，且随宫颈病变程度的加重而增高。研究组宫颈和肛门并发感染的发生率是对照组的5.3倍。与肛门的任何接触是并发HPV infection.Conclusions的发展的唯一显着的危险因素：并发肛门和宫颈HR HPV感染被发现在近一半的妇女与CIN2+。在两个解剖位置发现的优势基因型是HPV 16。任何频率和任何类型的肛门接触都是并发HPV感染的最重要危险因素。(C)2013年爱思唯尔B。V.保留所有权利。
Background: More than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor.Objectives: To demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer.Study design: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test.Results: Cervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection.Conclusions: Concurrent anal and cervical HR HPV infection was found in nearly half of women with CIN2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection. (C) 2013 Elsevier B. V. All rights reserved.