A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop.
A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop.
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基于赠款的实验来培训临床研究者：临床癌症研究研讨会中的AACR/ASCO方法。
DOI：
10.1158/1078-0432.ccr-21-1799
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发表时间：
2021-10-15
期刊：
影响因子：
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通讯作者：
Vu NV
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文献类型：
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作者：
Von Hoff DD;Clark GM;Coltman CA;Disis ML;Eckhardt SG;Ellis LM;Foti M;Garrett-Mayer E;Gönen M;Hidalgo M;Hilsenbeck SG;Littlefield JH;LoRusso PM;Lyerly HK;Meropol NJ;Patel JD;Piantadosi S;Post DA;Regan MM;Shyr Y;Tempero MA;Tepper JE;Von Roenn J;Weiner LM;Young DC;Vu NV
为了满足肿瘤临床研究人员的需求，AACR和ASCO建立了临床癌症研究方法研讨会（MCCRW）。研讨会的目标是：(1)提供临床试验方法、设计和实施方面的培训；(2)确保临床试验符合联邦和国际伦理准则；(3)评价车间的有效性；(4)通过指导资深教师，为年轻研究者创造交流机会。教育方法包括：(1)说教式讲座；(2)小组讨论；(3)协议开发小组；(4)一对一辅导。学习的重点是制定IRB-ready协议，该协议在研讨会的最后一天提交。评价方法包括：(1)车间前和车间后测试；(2)学生工作坊评价；(3)教师对协议制定的评分；(4)研修后学生临床研究工作效率；(5)对车间进行独立评估。从1996年到2014年，来自不同背景的1932名学生参加了研讨会。学生的知识水平从研讨会前的考试到研讨会后的考试有显著提高（p < 0.001）。在所有课程中，学生的评价都非常好。在研讨会结束时，教师们认为92-100%的学生方案已经准备好提交IRB。中期和长期随访表明，超过92%的学生积极参与与患者相关的研究，66%的学生实施了5个或更多的方案。这个由nci赞助的MCCRW对临床医生在癌症研究中设计和实施临床试验的能力的培训产生了重大影响。
To address the need for clinical investigators in oncology, AACR and ASCO established the Methods in Clinical Cancer Research Workshop (MCCRW). The workshop’s objectives were to: (1) provide training in the methods, design, and conduct of clinical trials; (2) ensure that clinical trials met federal and international ethical guidelines; (3) evaluate the effectiveness of the workshop; and (4) create networking opportunities for young investigators with mentoring senior faculty. Educational methods included: (1) didactic lectures; (2) Small Group Discussion Sessions; (3) Protocol Development Groups; (4) one-on-one mentoring. Learning focused on the development of an IRB-ready protocol, which was submitted on the last day of the workshop. Evaluation methods included: (1) pre- and post-workshop tests; (2) students’ workshop evaluations; (3) faculty’s ratings of protocol development; (4) students’ productivity in clinical research after the workshop; (5) an independent assessment of the workshop. From 1996-2014, 1932 students from diverse backgrounds attended the workshop. There was a significant improvement in the students’ level of knowledge from the pre- to the post-workshop exams (p < 0.001). Across the classes, student evaluations were very favorable. At the end of the workshop, faculty rated 92-100% of the students’ protocols as ready for IRB submission. Intermediate and long-term follow-ups indicated that more than 92% of students were actively involved in patient-related research, and 66% had implemented five or more protocols. This NCI-sponsored MCCRW has had a major impact on the training of clinicians in their ability to design and implement clinical trials in cancer research.