Histological evaluation of apatite cement containing atelocollagen
Histological evaluation of apatite cement containing atelocollagen
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DOI：
10.4012/dmj.26.194
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发表时间：
2007-03-01
影响因子：
2.5
通讯作者：
Nagayama, Masaru
中科院分区：
文献类型：
--
作者：
Takechi, Masaaki;Miyamoto, Youji;Nagayama, Masaru
使用常规AC（c-AC）作为对照材料，评价了对含去端胶原（AC（ate））的磷灰石水泥（AC）的组织反应。在一周时，AC（ate）和c-AC之间的唯一差异是软组织反应。对于c-AC，表现出中度炎症反应：小颗粒的c-AC分散在皮肤组织中，许多异物巨细胞聚集在分散的c-AC周围，而AC（ate）仅表现出轻微的炎症反应，异物巨细胞很少。在骨组织反应方面，在4周时观察到AC（ate）和c-AC之间的差异。在c-AC和AC（ate）中，在既存皮质骨边缘观察到沿着骨水泥的新骨形成。然而，在AC（ate）的情况下，与c-AC相比，在骨髓中沿着骨水泥形成了更丰富和更厚的新骨。
Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC.