Neural computations underlying contextual processing in humans.
Neural computations underlying contextual processing in humans.
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DOI：
10.1016/j.celrep.2022.111395
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发表时间：
2022-09-20
期刊：
影响因子：
8.8
通讯作者：
Lin, Jack J.
中科院分区：
文献类型：
--
作者：
Zheng, Jie;Skelin, Ivan;Lin, Jack J.
在日常社交中，环境塑造了我们对面部表情的感知。我们在充满敌意的情况下对一个人的脸进行负面解读，而在令人愉快的情况下对同一张脸进行正面判断。语境对我们的适应能力至关重要，它提供了针对具体情况的框架，以解决歧义并指导我们的人际行为。这种特定于背景的面部表情调节被认为涉及杏仁核、海马体和眼眶前额皮质；然而，潜在的神经计算仍然未知。在这里，我们使用直接从这些区域记录的人类颅内脑电(EEGs)，并报告杏仁核-海马体网络中的双向theta-Gamma相互作用，促进上下文处理。语境信息随后被呈现在眼眶前额叶皮质，在那里，theta相移将语境和面孔联系在theta周期内，赋予面孔在行为时间尺度上的语境意义。我们的结果发现，theta相移是背景和面孔加工之间的中介联系，支持灵活的社会行为。环境会影响我们对面部表情的感知。郑等人。表明人脸的语境调制依赖于人类内侧颞叶-眶前叶皮质的通讯。高伽马爆发与theta振荡有节奏地发生，跨区域的theta-Gamma相移绑定上下文-面部关联。
Context shapes our perception of facial expressions during everyday social interactions. We interpret a person’s face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, context provides situation-specific framing to resolve ambiguity and guide our interpersonal behavior. This context-specific modulation of facial expression is thought to engage the amygdala, hippocampus, and orbitofrontal cortex; however, the underlying neural computations remain unknown. Here we use human intracranial electroencephalograms (EEGs) directly recorded from these regions and report bidirectional theta-gamma interactions within the amygdala-hippocampal network, facilitating contextual processing. Contextual information is subsequently represented in the orbitofrontal cortex, where a theta phase shift binds context and face associations within theta cycles, endowing faces with contextual meanings at behavioral timescales. Our results identify theta phase shifts as mediating associations between context and face processing, supporting flexible social behavior. Context influences our perception of facial expressions. Zheng et al. show that contextual modulation of faces relies on medial temporal lobe-orbitofrontal cortex communications in humans. High gamma bursts occur in rhythm with theta oscillations, with cross-regional theta-gamma phase shifts binding context-face associations.
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