An artificial molecular pump
An artificial molecular pump
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DOI：
10.1038/nnano.2015.96
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发表时间：
2015-06-01
影响因子：
38.3
通讯作者：
Stoddart, J. Fraser
中科院分区：
文献类型：
--
作者：
Cheng, Chuyang;McGonigal, Paul R.;Stoddart, J. Fraser
载体蛋白消耗燃料，以便泵送离子或分子穿过细胞膜，产生浓度梯度。它们完全通过非共价键相互作用来控制扩散途径，这激发了化学家们设计模仿它们功能的人工系统。在这里，我们报告了一种完全人工合成的化合物，它作用于小分子，在其局部浓度中产生梯度。它通过使用氧化还原能和精确组织的非共价键相互作用来从溶液中泵出带正电荷的环，并将它们诱捕在低聚亚甲基链周围，作为动力学捕获缠结的一部分。哑铃形分子泵核心的氧化还原活性紫精单元起着双重作用，在氧化还原循环过程中首先吸引然后排斥环，从而以极简主义设计制定闪烁能量棘轮机制。我们的人工分子泵重复工作两个周期的操作和驱动环远离平衡向更高的局部浓度。
Carrier proteins consume fuel in order to pump ions or molecules across cell membranes, creating concentration gradients. Their control over diffusion pathways, effected entirely through noncovalent bonding interactions, has inspired chemists to devise artificial systems that mimic their function. Here, we report a wholly artificial compound that acts on small molecules to create a gradient in their local concentration. It does so by using redox energy and precisely organized noncovalent bonding interactions to pump positively charged rings from solution and ensnare them around an oligomethylene chain, as part of a kinetically trapped entanglement. A redox-active viologen unit at the heart of a dumbbell-shaped molecular pump plays a dual role, first attracting and then repelling the rings during redox cycling, thereby enacting a flashing energy ratchet mechanism with a minimalistic design. Our artificial molecular pump performs work repetitively for two cycles of operation and drives rings away from equilibrium toward a higher local concentration.