Low-temperature deacylation of N-monosubstituted amides.
Low-temperature deacylation of N-monosubstituted amides.
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DOI：
10.1021/ol048852h
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发表时间：
2004-10
期刊：
影响因子：
5.2
通讯作者：
A. Spaggiari;L. Blaszczak;F. Prati
中科院分区：
文献类型：
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作者：
A. Spaggiari;L. Blaszczak;F. Prati
（PhO）(3)P.Cl(2)试剂是用氯滴定亚磷酸三苯酯溶液原位制备的，用于将n -单取代酰胺转化为相应的胺。与其他传统方法相比，该反应具有条件温和、温度低（-30℃- 100℃）的优点。
[reaction: see text] The (PhO)(3)P.Cl(2) reagent, prepared in situ by titrating a solution of triphenyl phosphite with chlorine, is used to convert N-monosubstituted amides into their corresponding amines. The reaction, if compared to other traditional methods, shows the advantage of very mild conditions and low temperature (-30 degrees C-->rt).