The Obama Administration's Cancer Moonshot: A Call for Proteomics
The Obama Administration's Cancer Moonshot: A Call for Proteomics
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DOI：
10.1158/1078-0432.ccr-16-0688
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发表时间：
2016-09-15
影响因子：
11.5
通讯作者：
Petricoin, Emanuel F., III
中科院分区：
文献类型：
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作者：
Conrads, Thomas P.;Petricoin, Emanuel F., III
癌症登月计划已经启动，代表了一个潜在的范式转变倡议，其目标是实施一项集中的国家努力，使抗癌进展速度翻一番。精准医学、免疫疗法、基因组学和联合疗法的放置被置于这一倡议的中心节点。虽然我们对该计划的目标非常热情，但现在是我们以同样大胆和前沿的想法迎接这一革命性项目的时候了：现在是我们坚定地进入后基因组时代并提供必要的资源来推动和抓住蛋白质组学领域的最新创新成果的时候了。毕竟，虽然基因组是信息档案，但实际上是蛋白质完成细胞的工作并代表结构细胞机器。正是这些蛋白质构成了大多数用于检测癌症的生物标志物，构成了驱动免疫反应以及细胞间和细胞内通信的抗原，并且这些蛋白质是当今癌症试验中正在评估的几乎每种靶向治疗的药物靶标。我们认为，肿瘤微环境的综合系统生物学观点将癌症研究导向功能蛋白质组，磷酸化蛋白质组和细胞生物化学，这对于实现癌症登月计划的承诺至关重要。(C)2016年AACR。
The Cancer Moonshot Program has been launched and represents a potentially paradigm-shifting initiative with the goal to implement a focused national effort to double the rate of progress against cancer. The placement of precision medicine, immunotherapy, genomics, and combination therapies was placed at the central nexus of this initiative. Although we are extremely enthusiastic about the goals of the program, it is time we meet this revolutionary project with equally bold and cutting-edge ideas: it is time we move firmly into the post-genome era and provide the necessary resources to propel and seize on innovative recent gains in the field of proteomics required for it to stand on equal footing in this narrative as a combined, synergistic engine for molecular profiling. After all, although the genome is the information archive, it is the proteins that actually do the work of the cell and represent the structural cellular machinery. It is the proteins that comprise most of the biomarkers that are measured to detect cancers, constitute the antigens that drive immune response and inter-and intracellular communications, and it is the proteins that are the drug targets for nearly every targeted therapy that is being evaluated in cancer trials today. We believe that a combined systems biology view of the tumor microenvironment that orients cancer studies back to the functional proteome, phosphoproteome, and biochemistry of the cell will be essential to deliver on the promise of the Cancer Moonshot Program. (C) 2016 AACR.