Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear
Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear
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DOI：
10.1101/lm.60406
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Maren, S
中科院分区：
文献类型：
--
作者：
Garcia, R;Chang, CH;Maren, S
损伤研究表明，没有内侧前额叶皮层（mPFC）的大鼠很难回忆前一天获得的恐惧消退。一些电生理学研究也支持这一观察结果，证明了mPFC中神经元活动的抑制相关增加参与了恐惧消退的表达。然而，最近的一项研究表明，在某些情况下，在没有mPFC增强的情况下，恐惧消退可以被回忆起来，这表明其他回路的贡献。在此，我们通过对大鼠进行听觉恐惧条件反射、消退训练和7 d后的消退保持试验来验证这种可能性。在mPFC、运动皮质（MO）、背侧隔（SEP）或内侧背丘脑（MD）中进行电解损伤，因为它们可能参与条件性恐惧抑制;还进行了包括mPFC与MO、SEP或MD的联合损伤。损伤在预处理前1周或消退训练后1天进行。所有大鼠在消退训练期间正常地消退其条件性冻结行为，并且在保持测试期间没有显示出这种行为的任何恢复。这些数据表明，mPFC是不需要的收购，表达，或检索的灭绝记忆，但不排除的可能性，mPFC通常参与这些过程。
Lesion Studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also Supported this observation by demonstrating that extinction-related increases in neuronal activity in the mPFC participate in expression of fear extinction. However, a more recent Study has shown that fear extinction can be recalled, in certain circumstances, without mPFC potentiation, Suggesting contribution of other circuits. Here, we examined this possibility in rats that were Subjected to auditory fear conditioning, extinction training, and extinction retention test 7 d later. Electrolytic lesions were made in the mPFC, the motor cortex (MO), the dorsal Septum (SEP), or the mediodorsal thalamus (MD), because of their potential participation in conditioned fear inhibition; combined lesions including the mPFC with the MO, SEP, or MD were also made. The lesions were made either 1 wk before conditioning or 1 d after extinction training. All rats normally extinguished their conditioned freezing behavior during extinction training and did not display any return of this behavior during the retention test. These data reveal that the mPFC is not required for the acquisition, the expression, or the retrieval of extinction memories but do not exclude the possibility that the mPFC normally participates in these processes.