COMPOSITION OF WEIGHT LOST DURING SHORT-TERM WEIGHT-REDUCTION - METABOLIC RESPONSES OF OBESE SUBJECTS TO STARVATION AND LOW-CALORIE KETOGENIC AND NON-KETOGENIC DIETS
COMPOSITION OF WEIGHT LOST DURING SHORT-TERM WEIGHT-REDUCTION - METABOLIC RESPONSES OF OBESE SUBJECTS TO STARVATION AND LOW-CALORIE KETOGENIC AND NON-KETOGENIC DIETS
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DOI：
10.1172/jci108519
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发表时间：
1976-01-01
影响因子：
15.9
通讯作者：
VANITALLIE, TB
中科院分区：
文献类型：
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作者：
YANG, MU;VANITALLIE, TB
在三个10天的时间内，在6名肥胖受试者中测定饥饿、800千卡混合饮食和800千卡生酮（低碳水化合物-高脂肪）饮食对体重减轻的组成的影响。能量-氮平衡法用于量化体重减轻的3种可测量成分：蛋白质、脂肪和水。在800大卡生酮饮食中，受试者体重减轻（平均值±. SE）466.6 .+-。51.3在等热量的混合饮食中，以常规比例提供碳水化合物和脂肪，他们损失了277.9 ±。32.1 g/天。生酮饮食期间体重减轻的组成（百分比）为水61.2，脂肪35.0，蛋白质3.8。在混合日粮中，损失的组成是水37.1，脂肪59.5，蛋白质3.4。生酮饮食期间脂肪损失的平均量（g/天）为163.4;等热量混合饮食期间为166.7。生酮饮食期间的平均蛋白质损失（g/天）为17.9;混合饮食期间为9.5。在饥饿期间，平均体重减轻率为750.7 ± 0.05。50.9 g/天，组成（百分比）为水60.9，脂肪32.4，蛋白质6.7。饥饿期间蛋白质和脂肪的平均损失（克/天）为50.4 ±。4.6和243.1 .+-。14.6，分别。尿排泄的能量产生的材料（主要是酮）增加了16和32千卡/天，生酮和饥饿期间，分别。基础代谢率（kcal/24 h）不受还原方案性质的影响，但在50天研究期间与体重减轻成正比。因此，在10天的时间内，在坚持800千卡饮食期间损失的身体成分的能量值受摄入的脂肪和碳水化合物比例的广泛变化的影响最小。生酮与非生酮等热量方案诱导的体重减轻率的差异几乎完全是由水平衡的差异引起的。脂肪损失率是能量缺乏程度的函数。
The effects of starvation, an 800 kcal mixed diet and an 800 kcal ketogenic (low carbohydrate-high fat) diet on the composition of weight lost were determined in each of 6 obese subjects during three 10-day periods. The energy-N balance method was used to quantify the 3 measurable components of weight loss: protein, fat and water. On the 800 kcal ketogenic diet, subjects lost (mean .+-. SE) 466.6 .+-. 51.3 g/day; on the isocaloric mixed diet, which provided carbohydrate and fat in conventional proportions, they lost 277.9 .+-. 32.1 g/day. Composition of weight lost (percentage) during the ketogenic diet was water 61.2, fat 35.0, protein 3.8. During the mixed diet, composition of loss was water 37.1, fat 59.5, protein 3.4. The mean quantity (g/day) of fat lost during the ketogenic diet was 163.4; during the isocaloric mixed diet, it was 166.7. Mean protein loss (g/day) during the ketogenic diet was 17.9; during the mixed diet, it was 9.5. During starvation, mean rate of weight loss was 750.7 .+-. 50.9 g/day, the composition (percentage) being water 60.9, fat 32.4, protein 6.7. Mean protein and fat losses (g/day) during starvation were 50.4 .+-. 4.6 and 243.1 .+-. 14.6, respectively. Urinary excretion of energy yielding materials (largely ketones) increased by 16 and 32 kcal/day during ketogenic and starvation periods, respectively. Basal metabolic rates (kcal/24 h) were unaffected by the nature of the reducing regimen, but decreased in direct proportion to weight loss during the 50-day study period. Thus over a 10-day period, the energy value of body constituents lost during adherence to an 800 kcal diet is minimally affected by wide variations in the proportions of fat and carbohydrate ingested. Discrepancies in rate of weight loss induced by ketogenic vs. nonketogenic isocaloric regimens result almost entirely from differences in water balance. Rate of fat loss is a function of degree of energy deficit.