Cell Type-Specific Separation of Subicular Principal Neurons during Network Activities
Cell Type-Specific Separation of Subicular Principal Neurons during Network Activities
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DOI：
10.1371/journal.pone.0123636
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发表时间：
2015-04-14
期刊：
影响因子：
3.7
通讯作者：
Gloveli, Tengis
中科院分区：
文献类型：
--
作者：
Eller, Joanna;Zarnadze, Shota;Gloveli, Tengis
海马输出结构，下托，表达两个主要的记忆相关的网络节奏，尖波涟漪和伽马频率振荡。到目前为止，仍不清楚两种不同类型的下托主细胞，内在的爆发和定期尖峰神经元，参与这两个网络的节奏。使用伴随的局部场电位和细胞内记录在体外小鼠模型，允许两个网络的节奏的调查，我们发现了一个细胞类型特异性分离的主要神经元参与固有的爆裂和非参与定期尖峰细胞。然而，如果常规尖峰细胞保持在更去极化的水平，它们确实以特定的方式参与，这表明依赖于兴奋水平的潜在双峰工作模型。此外，内在的爆裂和规则的尖峰细胞表现出不同的内在膜和突触的活性网络的属性。因此，我们的研究结果表明，在网络活动期间，主细胞的细胞类型特异性分离成两个独立的组，支持下托内两个平行的信息处理流的想法。
The hippocampal output structure, the subiculum, expresses two major memory relevant network rhythms, sharp wave ripple and gamma frequency oscillations. To this date, it remains unclear how the two distinct types of subicular principal cells, intrinsically bursting and regular spiking neurons, participate in these two network rhythms. Using concomitant local field potential and intracellular recordings in an in vitro mouse model that allows the investigation of both network rhythms, we found a cell type-specific segregation of principal neurons into participating intrinsically bursting and non-participating regular spiking cells. However, if regular spiking cells were kept at a more depolarized level, they did participate in a specific manner, suggesting a potential bimodal working model dependent on the level of excitation. Furthermore, intrinsically bursting and regular spiking cells exhibited divergent intrinsic membrane and synaptic properties in the active network. Thus, our results suggest a cell-type-specific segregation of principal cells into two separate groups during network activities, supporting the idea of two parallel streams of information processing within the subiculum.