STAGE-DEPENDENT TOXICITY OF N-ACETYL-GLUCOSAMINE TO PLASMODIUM-FALCIPARUM
STAGE-DEPENDENT TOXICITY OF N-ACETYL-GLUCOSAMINE TO PLASMODIUM-FALCIPARUM
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DOI：
10.1111/j.1550-7408.1985.tb03020.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
VANDERBERG, JP
中科院分区：
文献类型：
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作者：
GUPTA, SK;SCHULMAN, S;VANDERBERG, JP
通过形态观察和~3H-次黄嘌呤掺入法评价了N-乙酰氨基葡萄糖对恶性疟原虫同步化培养物生长的影响。在红细胞周期的后期，~3H-次黄嘌呤掺入的抑制作用更为明显。在糖浓度为20 mM时，有害影响主要是由于释放的裂殖子不能侵入红细胞，而不是裂殖体不能成熟或释放裂殖子。这些结果与裂殖子上的凝集素样物质与红细胞表面糖蛋白相互作用的假设是一致的，该糖蛋白上的糖残基可能参与了这种识别。
The effects of N-acetylglucosamine on growth of synchronized cultures of P. falciparum were assessed by morphological observations and by measurement of parasite incorporation of 3H-hypoxanthine. Inhibition of 3H-hypoxanthine incorporation was more marked during the later stages of the erythrocytes cycle. At concentrations of the sugar < 20 mM the deleterious effects were mainly a result of failure of released merozoites to invade erythrocytes, rather than a failure of schizonts to mature or release merozoites. These results are compatible with the hypothesis that a lectin-like substance on the merozoite interacts with a surface glycoprotein on the red cell and that sugar residues on this glycoprotein may be involved in this recognition.