A DIFFERENTIAL-AVIDITY MODEL FOR T-CELL SELECTION
A DIFFERENTIAL-AVIDITY MODEL FOR T-CELL SELECTION
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DOI：
10.1016/0167-5699(94)90174-0
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发表时间：
1994-08-01
期刊：
影响因子：
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通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
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作者：
ASHTONRICKARDT, PG;TONEGAWA, S
胸腺发育过程中的正选择和负选择过程塑造了 T 细胞表现出的抗原特异性。这消除了动物体内潜在的自身反应性 T 细胞，同时确保它们能够对主要组织相容性复合物 (MHC) 限制性识别抗原。矛盾的是，这两个过程都涉及未成熟胸腺细胞上的 T 细胞受体 (TCR) 与胸腺基质细胞上表达的肽/MHC 复合物的结合。 Philip Ashton-Rickardt 和 Susumu Tonekawa 在此提出，决定这种相互作用结果的关键参数是肽/MHC 复合物占据的 TCR 数量，而这又是由 TCR-MHC 相互作用的亲和力决定的：低亲和力导致正选择，高亲和力导致负选择。
The processes of positive and negative selection during thymic development shape the repertoires of antigen specificities displayed by T cells. This rids the animal of potentially autoreactive T cells and, at the same time, ensures that they are capable of major histocompatibility complex (MHC)-restricted recognition of antigen. Paradoxically, both processes involve the engagement of the T-cell receptor (TCR) on immature thymocytes with peptide/MHC complexes expressed on thymic stromal cells. Here, Philip Ashton-Rickardt and Susumu Tonegawa suggest that the critical parameter determining the outcome of this interaction is the number of TCRs occupied by peptide/MHC complexes and that this, in turn, is determined by the avidity of the TCR-MHC interaction: low avidity resulting in positive selection and high avidity resulting in negative selection.