The community structure of human cellular signaling network.
The community structure of human cellular signaling network.
复制标题
人类细胞信号网络的社区结构。
DOI：
10.1016/j.jtbi.2007.04.007
复制
发表时间：
2007-08-21
影响因子：
2
通讯作者：
Pan Y
中科院分区：
文献类型：
--
作者：
Diao Y;Li M;Feng Z;Yin J;Pan Y
Living cell is highly responsive to specific chemicals in its environment, such as hormones and molecules in food or aromas. The reason is ascribed to the existence of widespread and diverse signal transduction pathways, between which crosstalks usually exist, thus constitute a complex signaling network. Evidently, knowledge of topology characteristic of this network could contribute a lot to the understanding of diverse cellular behaviors and life phenomena thus come into being. In this presentation, signal transduction data is extracted from KEGG to construct a cellular signaling network of Homo sapiens, which has 931 nodes and 6798 links in total. Computing the degree distribution, we find it is not a random network, but a scale-free network following a power-law of P(K)∼K−γ, with γ approximately equal to 2.2. Among three graph partition algorithms, the Guimera's simulated annealing method is chosen to study the details of topology structure and other properties of this cellular signaling network, as it shows the best performance. To reveal the underlying biological implications, further investigation is conducted on ad hoc community and sketch map of individual community is drawn accordingly. The involved experiment data can be found in the supplementary material.
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影响因子：
4.1
作者：
CHOU, KC;FORSEN, S
通讯作者：
FORSEN, S
影响因子：
64.8
作者：
Gavin, AC;Bösche, M;Superti-Furga, G
通讯作者：
Superti-Furga, G
影响因子：
2
作者：
CHOU, KC
通讯作者：
CHOU, KC
影响因子：
64.8
作者：
Albert, R;Jeong, H;Barabási, AL
通讯作者：
Barabási, AL
影响因子：
56.9
作者：
Barabási, AL;Albert, R
通讯作者：
Albert, R