Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
复制标题
马铃薯配糖生物碱对胆碱酯酶的抑制作用会减慢米库溴铵的代谢。
DOI：
10.1097/00000542-200008000-00031
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发表时间：
2000
期刊：
影响因子：
8.8
通讯作者：
Moss,J
中科院分区：
文献类型：
--
作者：
McGehee,DS;Krasowski,MD;Fung,DL;Wilson,B;Gronert,GA;Moss,J
背景：许多药物的作用时间取决于它们被内源性水解酶分解。与这些酶系统相互作用的饮食因素可能改变药物疗效和时间过程。胆碱酯酶如乙酰胆碱酯酶（AChE）和丁基胆碱酯酶（BuChE）可以水解和灭活几种麻醉药物，包括可卡因、海洛因、艾司洛尔、局部酯类麻醉剂和神经肌肉阻断药物。由茄科植物（包括土豆和西红柿）产生的天然糖生物碱毒素可抑制AChE和BuChE。在这里，作者评估了两种茄类糖生物碱(SGAs) -茄碱和茶碱在体内和体外改变神经肌肉阻断药物和胆碱酯酶抑制剂作用的程度。方法：纯化人乙酰胆碱酯酶和BuChE的抑制作用
Background: The duration of action for many pharmaceuti-cal agents is dependent on their breakdown by endogenous hydrolytic enzymes. Dietary factors that interact with these enzyme systems may alter drug efficacy and time course. Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. Natural glycoalkaloid toxins produced by plants of the family Solanaceae, which includes potatoes and tomatoes, inhibit both AChE and BuChE. Here the authors assess the extent to which two solanaceous glycoalkaloids (SGAs),-solanine and-chaconine, can alter the effects of neuromuscular blocking drugs and cholinesterase inhibitors in vivo and in vitro. Methods: Inhibition of purified human AChE and BuChE by