The Versatility of Sirtuin-1 in Endocrinology and Immunology.
The Versatility of Sirtuin-1 in Endocrinology and Immunology.
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DOI：
10.3389/fcell.2020.589016
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发表时间：
2020
影响因子：
5.5
通讯作者：
Pruitt K
中科院分区：
文献类型：
--
作者：
Rasha F;Mims BM;Castro-Piedras I;Barnes BJ;Grisham MB;Rahman RL;Pruitt K
Sirtuins属于NAD依赖性组蛋白去乙酰化酶（HDAC）的III类家族，并且参与多种生理过程，其范围从代谢和内分泌功能的调节到免疫和细胞对应激的反应的协调。Sirtuin-1（SIRT 1）是研究最充分的家族成员，并已被证明与表观遗传学，免疫学和内分泌学密切相关。SIRT 1的多功能作用包括调节能量感应代谢稳态、许多组织中组蛋白和非组蛋白蛋白的脱乙酰化、通过刺激下丘脑-垂体轴的神经内分泌调节、通过类固醇生成的生殖激素的合成和维持、通过调节T细胞和B细胞成熟的先天性和适应性免疫系统的维持、慢性炎症和自身免疫性疾病。此外，SIRT 1在各种疾病背景下是一个有吸引力的靶标，这是由于在内分泌和免疫相关疾病模型的背景下SIRT 1活性的药理学和/或天然调节剂的前景。在这篇综述中，我们的目的是提供一个广泛的概述SIRT 1的作用，特别是在内分泌学和免疫学的背景下。
Sirtuins belong to the class III family of NAD-dependent histone deacetylases (HDAC) and are involved in diverse physiological processes that range from regulation of metabolism and endocrine function to coordination of immunity and cellular responses to stress. Sirtuin-1 (SIRT1) is the most well-studied family member and has been shown to be critically involved in epigenetics, immunology, and endocrinology. The versatile roles of SIRT1 include regulation of energy sensing metabolic homeostasis, deacetylation of histone and non-histone proteins in numerous tissues, neuro-endocrine regulation via stimulation of hypothalamus-pituitary axes, synthesis and maintenance of reproductive hormones via steroidogenesis, maintenance of innate and adaptive immune system via regulation of T- and B-cell maturation, chronic inflammation and autoimmune diseases. Moreover, SIRT1 is an appealing target in various disease contexts due to the promise of pharmacological and/or natural modulators of SIRT1 activity within the context of endocrine and immune-related disease models. In this review we aim to provide a broad overview on the role of SIRT1 particularly within the context of endocrinology and immunology.
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DOI：
10.1007/978-3-030-02278-5_91
发表时间：
2019-01-01
期刊：
EBMT HANDBOOK: HEMATOPOIETIC STEM CELL TRANSPLANTATION AND CELLULAR THERAPIES
影响因子：
--
作者：
Alexander, Tobias;Sharrack, Basil;Snowden, John A.
通讯作者：
Snowden, John A.
影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
影响因子：
3.7
作者：
Cea M;Soncini D;Fruscione F;Raffaghello L;Garuti A;Emionite L;Moran E;Magnone M;Zoppoli G;Reverberi D;Caffa I;Salis A;Cagnetta A;Bergamaschi M;Casciaro S;Pierri I;Damonte G;Ansaldi F;Gobbi M;Pistoia V;Ballestrero A;Patrone F;Bruzzone S;Nencioni A
通讯作者：
Nencioni A
影响因子：
8
作者：
Caruso, R.;Marafini, I.;Monteleone, G.
通讯作者：
Monteleone, G.
影响因子：
3.7
作者：
Akieda-Asai S;Zaima N;Ikegami K;Kahyo T;Yao I;Hatanaka T;Iemura S;Sugiyama R;Yokozeki T;Eishi Y;Koike M;Ikeda K;Chiba T;Yamaza H;Shimokawa I;Song SY;Matsuno A;Mizutani A;Sawabe M;Chao MV;Tanaka M;Kanaho Y;Natsume T;Sugimura H;Date Y;McBurney MW;Guarente L;Setou M
通讯作者：
Setou M