Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic.
Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic.
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DOI：
10.1007/s11916-007-0191-7
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发表时间：
2007-06-01
影响因子：
3.7
通讯作者：
Becerra, Lino
中科院分区：
文献类型：
--
作者：
Borsook, David;Becerra, Lino
功能性磁共振成像（fMRI）为慢性疼痛的大脑机制提供了新的见解。然而，与健康志愿者的急性疼痛测量不同，这些患者的脑回路映射还有其他问题。这些包括测量诱发性疼痛与自发性疼痛的能力，背景条件如药物，或共病疾病如抑郁症，焦虑症或成瘾。尽管如此，我们对疼痛的集中性以及伴随的感觉、情绪和自主神经功能变化的理解正在得到更清楚的认识，这对定义疾病状态和治疗干预具有重要意义。功能性磁共振成像有可能在临床上发挥作用。
Functional MRI (fMRI) has provided new insights into brain mechanisms in chronic pain. However, unlike acute pain measures in healthy volunteers, there are additional concerns relating to mapping brain circuits in these patients. These include the ability to measure evoked versus spontaneous pain, background conditions such as medications, or comorbid diseases such as depression, anxiety, or addiction. Nevertheless, our understanding of the centralization of pain with attendant changes in sensory, emotional, and autonomic function is being more clearly realized and has significant implications for defining the disease state and therapeutic interventions. It is possible that fMRI may become clinically useful.