New players in cytokine control of HIV infection.
New players in cytokine control of HIV infection.
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DOI：
10.1007/s11904-008-0005-5
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发表时间：
2008-02-01
影响因子：
4.6
通讯作者：
Poli, Guido
中科院分区：
文献类型：
--
作者：
Alfano, Massimo;Crotti, Andrea;Poli, Guido
Cytokines are involved early in the pathogenesis of HIV infection and disease progression as a component of immunologic dysregulation and immunodeficiency and as determinants controlling virus replication. Several steps, before and after retroviral integration into host DNA in T cells and macrophages, are affected by cytokines whereas CCR5 and CXCR4 binding chemokines can interfere with viral entry. A growing number of potential players--including the gamma-common interleukin (IL)-7, IL-15, and IL-21 together with IL-17, IL-18, IL-19, IL-20, IL-23, and IL-27--are discussed in terms of their perturbation in HIV infection and of their effects on virus replication. Thus, an increasing intersection of HIV infection and the cytokine network represents a crucial determinant of virus replication and immunologic dysregulation and will likely play a key role in the development of effective strategies of HIV prevention and immunologic reconstitution.
