Smoking and health outcomes after percutaneous coronary intervention.
Smoking and health outcomes after percutaneous coronary intervention.
复制标题
吸烟与经皮冠状动脉介入治疗后的健康结果。
DOI：
10.1067/mhj.2003.67
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发表时间：
2003
影响因子：
4.8
通讯作者：
Spertus,John
中科院分区：
文献类型：
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作者：
Haddock,CKeith;Poston,WalkerSC;Taylor,JenniferE;Conard,Mark;Spertus,John
本研究旨在描述吸烟对经皮冠状动脉介入治疗（PCI）后健康状况和死亡率的影响。方法在密苏里州堪萨斯城圣卢克医院中美洲心脏研究所的271例连续PCI患者队列中进行前瞻性观察研究。在基线和干预后6个月和12个月进行包括健康状况评估在内的调查。主要结局是通过简明健康状况量表（SF-12）和西雅图心绞痛问卷（SAQ）测量的健康状况。结果风险调整的统计模型表明，在许多健康相关的生活质量领域，目前吸烟的患者比其他患者在血运重建后的健康状况更差。例如，从未吸烟的患者（P < .001）和曾经吸烟的患者（P < .001）在SF-12的身体成分评分上的得分显著高于目前吸烟的患者，这表明他们对整体身体功能的感觉更好。同样，从未吸烟的患者和曾经吸烟的患者在SAQ上报告的身体限制、心绞痛和生活质量显著低于当前吸烟的患者。吸烟状况与血运重建后12个月的死亡率无关。结论吸烟严重限制了PCI对健康状况的潜在益处。(Am Heart J 2003;145：652-7.）
Background This study was designed to describe the impact of smoking on health status and mortality after percutaneous coronary intervention (PCI). Methods A cohort of 271 consecutive PCI patients at the Mid-America Heart Institute of St Luke's Hospital in Kansas City, Mo, were observed in a prospective, observational study. Surveys that included health status assessments were administered at baseline and at 6 and 12 months after intervention. Primary outcome was health status as measured by the Short Form-12 (SF-12) and the Seattle Angina Questionnaire (SAQ). Results Risk-adjusted statistical models demonstrated that, across a number of health-related quality of life domains, patients who were current smokers had poorer health status outcomes than other patients after revascularization. For instance, patients who had never smoked (P < .001) and patients who were former smokers (P < .001) scored significantly higher than patients who were current smokers on the physical component score of the SF-12, which indicated a better sense of overall physical function. Similarly, patients who had never smoked and patients who were former smokers reported significantly fewer physical limitations, less angina, and a higher quality of life on the SAQ than patients who were current smokers. Smoking status was unrelated to mortality rate in the 12 months after revascularization. Conclusions Smoking substantially limits the potential health status benefits of PCI. (Am Heart J 2003;145:652-7.)