PDMS polymerized high internal phase emulsions (polyHIPEs) with closed-cell, aqueous-filled microcavities
PDMS polymerized high internal phase emulsions (polyHIPEs) with closed-cell, aqueous-filled microcavities
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DOI：
10.1039/c9sm01732a
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发表时间：
2019-12-21
期刊：
影响因子：
3.4
通讯作者：
Hutchens, Shelby B.
中科院分区：
文献类型：
--
作者：
Kataruka, Amrita;Hutchens, Shelby B.
乳液模板可以通过连续相的固化产生各种独特的微结构。当模板液滴发展成闭孔结构时，这些结构中的一些导致独特的、充满流体的复合材料，使人联想到生物组织。然而，由于刚性、脆性和生物不相容的材料，现有技术水平的福尔斯在复制生物结构的机械和功能响应方面存在不足，同时缺乏系统的处理参数。本文描述了高内相、闭孔聚二甲基硅氧烷（PDMS）弹性体泡沫的合成，这些泡沫同时实现生物相容性、机械稳健性、柔韧性和选择性渗透性。由二氧化硅纳米颗粒（SNP）稳定的油包水高内相乳液（HIPE）提供了微观结构模板，从而产生> 74体积%的水相（高达82%）。为了克服当使用机械上优越但高粘性的商业PDMS试剂盒时HIPE形成的阻碍性障碍，我们通过离心低内相乳液（LIPE，
Emulsion templates can produce a wide range of unique microstructures via solidification of the continuous phase. Some of these structures result in unique, fluid-filled composites reminiscent of biological tissue when the templating droplets develop into closed-cell structures. However, the state-of-the-art falls short in replicating the mechanical and functional response of biological structures due to stiff, fragile, and bio-incompatible materials while lacking systematic processing parameters. This article describes the synthesis of high internal phase, closed-cell, polydimethylsiloxane (PDMS) elastomeric foams which simultaneously achieve biocompatibility, mechanical robustness, flexibility, and selective permeability. Water-in-oil high internal phase emulsions (HIPEs) stabilized by silica nano-particles (SNPs) provide the microstructural template, resulting in a >74% by volume aqueous phase (up to 82%). To overcome the prohibitive barrier to HIPE formation when using a mechanically-superior, but highly viscous commercial PDMS kit, we produce HIPE templates via centrifugation of low internal phase emulsions (LIPEs,