From genes to drugs: target validation in Caenorhabditis elegans.
From genes to drugs: target validation in Caenorhabditis elegans.
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DOI：
10.1016/j.ddtec.2004.09.007
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发表时间：
2004-10-01
期刊：
影响因子：
--
通讯作者：
Baumeister, Ralf
中科院分区：
文献类型：
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作者：
Sluder, Ann E;Baumeister, Ralf
后基因组药物发现的一个核心挑战是从大量候选药物中选择相关的治疗靶点，以便有效地投资资源。应对这一挑战的关键是证明体内疾病相关途径中的靶功能。线虫秀丽隐杆线虫是一种用于生物调控途径遗传分析的良好表征的实验系统，提供了评估调节靶功能对生物过程的影响的有力手段，从而促进了高价值靶的选择。
A central challenge in post-genomic drug discovery is selection of relevant therapeutic targets from a large pool of candidates, so that resources are invested productively. Key to meeting this challenge is demonstrating target function in disease-related pathways in vivo. The nematode Caenorhabditis elegans, a well-characterized experimental system for genetic analysis of biological regulatory pathways, provides a powerful means of assessing the impact of modulating target function on biological processes, thus facilitating selection of high-value targets.: