H2O2-Sensitive Upconversion Nanocluster Bomb for Tri-Mode Imaging-Guided Photodynamic Therapy in Deep Tumor Tissue
H2O2-Sensitive Upconversion Nanocluster Bomb for Tri-Mode Imaging-Guided Photodynamic Therapy in Deep Tumor Tissue
复制标题
用于深部肿瘤组织三模式成像引导光动力治疗的 H2O2 敏感上转换纳米团簇炸弹
DOI：
10.1002/adhm.201900972
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发表时间：
2019-09-30
影响因子：
10
通讯作者：
Hu, Yong
中科院分区：
文献类型：
--
作者：
Jiang, Wei;Zhang, Chao;Hu, Yong
受激光穿透深度低、光敏剂分布不良、肿瘤内严重缺氧、活性氧（ROS）生成效率低下，导致光动力治疗效果不佳。本文研制了一种由上转化纳米颗粒（NPs）、CeOx、石墨- c3n4 (g-C3N4) NPs和二甲双胍（Met）组成的多功能纳米簇炸弹（UCGM naonopparticles），通过CeOx的催化将H2O2氧化成O-2来缓解缺氧。Met的存在可作用于线粒体抑制肿瘤细胞的呼吸，进一步提高O-2水平。同时，g-C3N4 NPs由于体积小，从UCGM NPs中释放出来，深入肿瘤组织。在808 nm激光照射下，UCGM NPs表现出卓越的光热能力，并有效地将近红外光转化为紫外光，激活g-C3N4 NPs在整个肿瘤中产生ROS，从而促进对深部肿瘤的联合抗肿瘤作用。此外，这些UCGM NPs在上转换发光、磁共振成像和计算机层析成像方面也表现出优异的性能，使其成为潜在的成像引导给药系统用于癌症治疗。
Low penetration depth of excited light, undesirable distribution of photosensitizers, severe hypoxia, and inefficient reactive oxygen species (ROS) generation in tumors, lead to the poor therapeutic effects in photodynamic therapy. Herein, a multifunctional nanocluster bomb (UCGM naonoparticles) composed of upconversion nanoparticles (NPs), CeOx, graphite-C3N4 (g-C3N4) NPs, and metformin (Met) are developed to mitigate the hypoxia by oxidizing H2O2 into O-2 due to the catalysis of CeOx. The presence of Met can act on the mitochondrion to inhibit the respiration of tumor cells, further improving the O-2 level. Meanwhile, g-C3N4 NPs are released from UCGM NPs and penetrate tumor tissue deeply because of their small size. Upon 808 nm laser illumination, UCGM NPs show remarkable photothermal ability and efficiently convert near infrared to ultraviolet light to activate the g-C3N4 NPs to generate ROS in a whole tumor to facilitate a combined antitumor effect against deeply located tumors. Moreover, these UCGM NPs also display excellent performances in upconversion luminescence, magnetic resonance imaging, and computerized tomographic imaging, making them a potential imaging-guided drug delivery system in cancer therapy.