Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma
Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma
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DOI：
10.1167/iovs.13-11676
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发表时间：
2013-05-01
影响因子：
4.4
通讯作者：
Medeiros, Felipe A.
中科院分区：
文献类型：
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作者：
Lisboa, Renato;Paranhos, Augusto, Jr.;Medeiros, Felipe A.
目的。比较谱域光学相干断层扫描 (SDOCT) 视网膜神经纤维层 (RNFL)、视神经乳头 (ONH) 和黄斑测量检测视野前青光眼损伤的能力。方法。该研究纳入了 91 名根据视盘外观怀疑患有该疾病的患者的 142 只眼睛。在成像之前，所有眼睛均具有正常视野。 48 只患有进行性青光眼损伤的眼睛被纳入视野前青光眼组。 94 只眼睛没有任何进行性青光眼损伤的证据，并且随访 12.8 +/- 3.6 年未接受治疗，被用作对照。计算受试者工作特征曲线 (AUC) 下的面积，以总结参数的诊断准确性。 结果。 AUC 最大的三个 RNFL 参数是平均 RNFL 厚度 (0.89 +/- 0.03)、下半球平均厚度 (0.87 +/- 0.03) 和下象限平均厚度 (0.85 +/- 0.03)。具有最大 AUC 的三个 ONH 参数是垂直杯盘比 (0.74 +/- 0.04)、边缘面积 (0.72 +/- 0.05) 和边缘体积 (0.72 +/- 0.05)。 AUC 最大的三个黄斑参数是 GCC 平均厚度 (0.79 +/- 0.04)、GCC 下厚度 (0.79 +/- 0.05) 和 GCC 上厚度 (0.76 +/- 0.05)。 RNFL 平均厚度优于垂直杯盘比（0.89 vs. 0.74；P = 0.007）和 GCC 平均厚度（0.89 vs. 0.79；P = 0.015）。结论。在检测一组青光眼疑似患者的视野前青光眼损伤方面，SDOCT RNFL 测量的表现优于 ONH 和黄斑测量。
PURPOSE. To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.METHODS. The study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session. Forty-eight eyes with progressive glaucomatous damage were included in the preperimetric glaucoma group. Ninety-four eyes without any evidence of progressive glaucomatous damage and followed untreated for 12.8 +/- 3.6 years were used as controls. Areas under the receiver operating characteristic curves (AUC) were calculated to summarize diagnostic accuracies of the parameters.RESULTS. The three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 +/- 0.03), inferior hemisphere average thickness (0.87 +/- 0.03), and inferior quadrant average thickness (0.85 +/- 0.03). The three ONH parameters with the largest AUCs were vertical cup-to-disc ratio (0.74 +/- 0.04), rim area (0.72 +/- 0.05), and rim volume (0.72 +/- 0.05). The three macular parameters with the largest AUCs were GCC average thickness (0.79 +/- 0.04), GCC inferior thickness (0.79 +/- 0.05), and GCC superior thickness (0.76 +/- 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P = 0.007) and GCC average thickness (0.89 vs. 0.79; P = 0.015).CONCLUSIONS. SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects.