Anticipatory racism stress, smoking and disease activity: the Black women's experiences living with lupus (BeWELL) study.
Anticipatory racism stress, smoking and disease activity: the Black women's experiences living with lupus (BeWELL) study.
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预期种族主义压力、吸烟和疾病活动：黑人女性狼疮患者的经历 (BeWELL) 研究。
DOI：
10.1007/s10865-021-00235-9
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发表时间：
2021
影响因子：
3.1
通讯作者：
Chae,DavidH
中科院分区：
文献类型：
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作者：
Spears,EricaC;Allen,AmaniM;Chung,KaraW;Martz,ConnorD;Hunter,EvelynA;Fuller-Rowell,ThomasE;Lim,SSam;Drenkard,Christina;Chae,DavidH
与白人女性相比，患有系统性红斑狼疮 (SLE) 的非洲裔美国女性的疾病结果更差。与种族相关的压力源可能会通过适应不良的行为途径导致该人群的健康状况恶化。这项研究调查了与预期种族主义、吸烟和系统性红斑狼疮疾病活动相关的压力之间的关系。数据来自黑人女性狼疮生活经历 (BeWELL) 研究中的 432 名患有系统性红斑狼疮的非裔美国女性。控制社会人口统计学和健康相关协变量后，多变量回归分析显示预期种族主义压力（ARS）与疾病活动之间存在显着关联（p = 0.00，b = 1.13，95% CI [0.43，1.82]）。 ARS 和吸烟之间的显着交互作用还表明，吸烟加剧了 ARS 对疾病活动性的影响（p = 0.04，b = 1.95，CI = 0.04，3.96）。吸烟介导 ARS 对疾病活动性影响的证据检验不具有统计学显着性（z = 1.77，p = 0.08）。研究结果对未来非裔美国系统性红斑狼疮女性的系统性红斑狼疮差异研究具有重要意义。
African American women with systemic lupus erythematosus (SLE) have worse disease outcomes compared to their White counterparts. Stressors associated with race may contribute to poorer health in this population through maladaptive behavioral pathways. This study investigated relationships between stress associated with anticipating racism, smoking, and SLE disease activity. Data were from 432 African American women with SLE in the Black Women’s Experiences Living with Lupus (BeWELL) Study. Controlling for sociodemographic and health-related covariates, multivariable regression analyses revealed a significant association between anticipatory racism stress (ARS) and disease activity (p = 0.00, b = 1.13, 95% CI [0.43, 1.82]). A significant interaction between ARS and smoking also indicated that smoking exacerbated the effect of ARS on disease activity (p = 0.04, b = 1.95, CI = 0.04, 3.96). Test for evidence of smoking mediating the effect of ARS on disease activity were not statistically significant (z = 1.77, p = 0.08). Findings have implications for future SLE disparities research among African American women with SLE.