Spi-B Promotes the Recruitment of Tumor-Associated Macrophages via Enhancing CCL4 Expression in Lung Cancer.
Spi-B Promotes the Recruitment of Tumor-Associated Macrophages via Enhancing CCL4 Expression in Lung Cancer.
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Spi-B 通过增强肺癌中 CCL4 的表达来促进肿瘤相关巨噬细胞的募集
DOI：
10.3389/fonc.2021.659131
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发表时间：
2021
影响因子：
4.7
通讯作者：
Du W
中科院分区：
文献类型：
--
作者：
Huang Q;Liu J;Wu S;Zhang X;Xiao Z;Liu Z;Du W
肿瘤免疫逃逸在恶性肿瘤的发展中起着至关重要的作用，并导致抗癌免疫治疗的失败。SPI-B是一种淋巴细胞系特异性ETS转录因子，参与人肺癌的间质侵袭和转移。然而，SPI-B调节肿瘤免疫环境的机制尚未阐明。在这项研究中，我们利用小鼠皮下模型和人类肺癌的临床样本，证明了SPI-B增强了肿瘤微环境中肿瘤相关巨噬细胞(TAMs)的渗透。Spi-B的过表达增加了极化和招募相关基因的表达，包括CCL4。此外，去除CCl_4抑制了SPI-B促进巨噬细胞浸润的能力。这些数据表明，SPI-B通过上调CCl4的表达促进TAMs在肿瘤微环境中的募集，从而促进肺癌的进展。
Tumor immune escape plays a critical role in malignant tumor progression and leads to the failure of anticancer immunotherapy. Spi-B, a lymphocyte lineage-specific Ets transcription factor, participates in mesenchymal invasion and favors metastasis in human lung cancer. However, the mechanism through which Spi-B regulates the tumor immune environment has not been elucidated. In this study, we demonstrated that Spi-B enhanced the infiltration of tumor-associated macrophages (TAMs) in the tumor microenvironment using subcutaneous mouse models and clinical samples of human lung cancer. Spi-B overexpression increased the expression of TAM polarization- and recruitment-related genes, including CCL4. Moreover, deleting CCL4 inhibited the ability of Spi-B promoting macrophage infiltration. These data suggest that Spi-B promotes the recruitment of TAMs to the tumor microenvironment via upregulating CCL4 expression, which contributes to the progression of lung cancer.
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DOI：
10.1016/j.biocel.2003.10.019
发表时间：
2004-10-01
影响因子：
4
作者：
Maurer, M;von Stebut, E
通讯作者：
von Stebut, E
影响因子：
11.2
作者：
Caetano MS;Zhang H;Cumpian AM;Gong L;Unver N;Ostrin EJ;Daliri S;Chang SH;Ochoa CE;Hanash S;Behrens C;Wistuba II;Sternberg C;Kadara H;Ferreira CG;Watowich SS;Moghaddam SJ
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Moghaddam SJ
影响因子：
82.9
作者：
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DOI：
10.1007/978-3-030-36667-4_3
发表时间：
2020-01-01
期刊：
TUMOR MICROENVIRONMENT: THE ROLE OF CHEMOKINES, PT A
影响因子：
--
作者：
Mukaida, Naofumi;Sasaki, So-ichiro;Baba, Tomohisa
通讯作者：
Baba, Tomohisa
Csf2 通过促进替代性巨噬细胞转变减轻脓毒症引起的急性肾损伤
影响因子：
7.3
作者：
Li, Yiming;Zhai, Pan;Peng, Zhiyong
通讯作者：
Peng, Zhiyong