Lung cancer screening with CT: Mayo Clinic experience
Lung cancer screening with CT: Mayo Clinic experience
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DOI：
10.1148/radiol.2263020036
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发表时间：
2003-03-01
期刊：
影响因子：
19.7
通讯作者：
Clemens, MA
中科院分区：
文献类型：
--
作者：
Swensen, SJ;Jett, JR;Clemens, MA
目得：为了评估一个大的肺癌高危患者队列，通过使用低剂量螺旋CT（CT）的胸部techniques.MATERIALS和METHODS：一项前瞻性队列研究进行了1,520名年龄在50岁或以上的人吸烟20包年或以上。参与者每年接受三次胸部和上腹部低剂量CT检查。结果：基线后两年，CT扫描在1,049名参与者（69%）中识别出2,832个未钙化的肺结节。40例肺癌被诊断：26例在基线（患病率）CT检查时，10例在随后的年度（发病率）CT检查时。单纯CT检查36例，单纯痰细胞学检查2例。有两个间隔癌细胞类型如下：鳞状细胞肿瘤，7，腺癌或细支气管肺泡癌，24大细胞肿瘤，2，非小细胞肿瘤，3，小细胞肿瘤，4。CT检测到的非小细胞癌的平均大小为15.0 mm。分期如下：IA，22; IB，3; IIA，4; IIB，1; IIIA，5; IV，1;局限性小细胞肿瘤，4。CT检测到的35例非小细胞癌中有21例（60%）在诊断时为Ia期。确定了696项具有临床重要性的额外发现。结论：CT可以描述早期肺癌。良性结节检出率高。((C))RSNA，2003年。
PURPOSE: To evaluate a large cohort of patients at high risk for lung cancer by using screening with low-dose spiral computed tomography (CT) of the chest.MATERIALS AND METHODS: A prospective cohort study was performed with 1,520 individuals aged 50 years or older who had smoked 20 pack years or more. Participants underwent three annual low-dose CT examinations of the chest and upper abdomen. Characteristics of pulmonary nodules and additional findings were tabulated and analyzed.RESULTS: Two years after baseline,CT scanning 2,832 uncalcified pulmonary nodules were identified in 1,049 participants (69%). Forty cases of lung cancer were diagnosed: 26 at baseline (prevalence) CT examinations and 10 at subsequent annual (incidence) CT examinations. CT alone depicted 36 cases: sputum cytologic examination alone, two. There were two interval cancers Cells types were as follows squamous cell tumour, seven, adenocarcinoma or bronchioloalveolar carcinoma, 24 large cell tumour, two, non-small cell tumour, three, small cell tumour, four. The mean size of the non-small cell cancers detected at CT was 15.0 mm. The stages were as follows: IA, 22; IB, three; IIA, four; IIB, one; IIIA, five; IV, one: limited small cell tumour, four. Twenty-one (60%) of the 35 non-small cell cancers detected at CT were stage Ia at diagnosis. Six hundred ninety-six additional findings of clinical importance were identified.CONCLUSION: CT can depict early stage lung cancers. The rate of benign nodule detection is high. ((C)) RSNA, 2003.