Intracisternal rat pancreatic polypeptide stimulates gastric emptying in the rat.
Intracisternal rat pancreatic polypeptide stimulates gastric emptying in the rat.
复制标题
脑池内大鼠胰多肽刺激大鼠胃排空。
DOI：
10.1152/ajpregu.1995.269.1.r167
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
StephensJr,RL
中科院分区：
文献类型：
--
作者：
McTigue,DM;Chen,CH;Rogers,RC;StephensJr,RL
胰腺多肽（PP）已被证明可以改变胃肠道功能，包括在脑干注射PP后增加胃酸分泌和运动。本研究探讨了脑池内注射PP对胃排空率的影响。此外，比较了大鼠和牛形式的肽的功效。用乙醚麻醉的大鼠接受脑池内注射大鼠PP、牛PP或溶剂，并在恢复意识后喂食液体试验餐。“与对照动物相比，脑池内大鼠PP在胃排空方面产生了显著的增强。牛PP，剂量等于或大于有效大鼠PP剂量的三倍，胃排空没有变化。在大鼠PP的中枢注射之前用全身性阿托品预处理消除了排空的刺激，表明PP通过胆碱能机制起作用。当等摩尔剂量的大鼠或牛PP直接显微注射到背迷走复合体，该地区含有PP受体，都能够刺激胃窦运动。然而，与大鼠PP相比，对牛PP的反应延迟并减少。结果表明，大鼠PP强烈刺激大鼠胃排空和牛PP，根据给药途径，是无效的或较弱的激动剂中央PP受体。
Pancreatic polypeptide (PP) has been shown to alter gastrointestinal functions, including increased gastric acid secretion and motility following brain stem injections of PP. The present study investigated the effect of an intracisternal injection of PP on the rate of gastric emptying. Additionally, the efficacy of the rat and bovine forms of the peptide was compared. Rats anesthetized with ether received an intracisternal injection of rat PP, bovine PP, or vehicle and, upon regaining consciousness, were fed a liquid test "meal." Intracisternal rat PP produced a marked enhancement in gastric emptying compared with control animals. Bovine PP, at doses equimolar to or three times greater than the effective rat PP dose, produced no change in gastric emptying. Pretreatment with systemic atropine prior to central injection of rat PP eliminated the stimulation of emptying, suggesting that PP acts through a cholinergic mechanism. When equimolar doses of rat or bovine PP were microinjected directly into the dorsal vagal complex, the region containing PP receptors, both were capable of stimulating antral motility. The response to bovine PP, however, was delayed and reduced compared with that seen following rat PP. The results suggest that rat PP strongly stimulates gastric emptying in rats and that bovine PP, depending on the route of administration, is either ineffectual or a weaker agonist for central PP receptors.