Blood nicotine, smoke exposure and tobacco withdrawal symptoms.
Blood nicotine, smoke exposure and tobacco withdrawal symptoms.
复制标题
血液尼古丁、烟雾暴露和烟草戒断症状。
DOI：
10.1016/0306-4603(85)90038-3
复制
发表时间：
1985
影响因子：
4.4
通讯作者：
Pickens,RW
中科院分区：
文献类型：
--
作者：
Hatsukami,DK;Hughes,JR;Pickens,RW
在20名吸烟者中研究了烟草戒断症状与吸烟前和吸烟后血液尼古丁水平、吸烟前可替宁水平、吸烟前至吸烟后尼古丁水平变化、尼古丁半衰期和总烟雾暴露量之间的关系。受试者报告的对尼古丁的渴望与血液尼古丁/可替宁水平以及吸烟前后尼古丁水平的变化显著相关;睡眠期间的混乱和觉醒次数的问卷测量与尼古丁的半衰期相关;睡眠期间的觉醒次数与总烟雾暴露的行为测量相关。这些结果表明，烟草戒断的一些症状与尼古丁剥夺有关，而另一些则无关。
The relationship between tobacco withdrawal symptoms and pre- and post-cigarette blood nicotine levels, pre-cigarette cotinine levels, change in nicotine level from pre- to post-cigarette, half-life for nicotine, and total smoke exposure was examined in 20 smokers. Subjects' reports of craving for cigaretts were significantly related to blood nicotine/cotinine levels and change in nicotine level from pre- to post-cigarette; questionnaire measures of confusion and number of awakenings during sleep was related to half-life for nicotine; and number of awakenings during sleep was related to behavioral measures of total smoke exposure. These results suggests some symptoms of tobacco withdrawal are related to nicotine deprivation while others are not.