Impact of a predefined mediastinal ROI on inter-observer variability of planar 123I-MIBG heart-to-mediastinum ratio
Impact of a predefined mediastinal ROI on inter-observer variability of planar 123I-MIBG heart-to-mediastinum ratio
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DOI：
10.1007/s12350-014-9854-z
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发表时间：
2014-06-01
影响因子：
2.4
通讯作者：
Verberne, Hein J.
中科院分区：
文献类型：
--
作者：
Verschure, Derk O.;Bongers, Vivian;Verberne, Hein J.
本研究的目的是评估纵隔感兴趣区 (ROI) 定义对观察者内和观察者间差异与准直器类型的影响。 纳入了 35 名 CHF 受试者（80% 为男性，平均年龄 66 +/- A 9 岁，NYHA 2.4 +/- A 0.5，LVEF 29 +/- A 8.4%）。 I-123-MIBG 注射 (p.i.) 15 分钟和 4 小时后，使用低能高能 (LEHR) 和中能 (ME) 准直器依次采集平面图像。在第一个分析中，使用了观察者定义的纵隔 ROI。在第二次分析中，使用了预定义的纵隔 ROI。使用 Lin 一致性系数 (LCC) 评估晚期 H/M 的观察者内部和观察者之间的变异性。使用预定义纵隔 ROI 的所有三位观察者之间达成了实质性一致。 LEHR 的 LCC 为 0.98、0.96 和 0.95，ME 为 0.98、0.97 和 0.97。然而，观察者定义的纵隔投资回报率导致了较差-中等的一致性。 LEHR 的 LCC 为 0.82、0.94 和 0.70，ME 为 0.77、0.91 和 0.80。使用预定义的纵隔 ROI 进行的观察者内分析显示出基本一致。 LEHR 的 LCC 为 0.97，ME 的 LCC 为 0.96。预定义的纵隔 ROI 导致晚期 H/M 观察者内和观察者间的变异性较低，因此优于观察者定义的纵隔 ROI。晚期 H/M 的观察者内部和观察者之间的变异性不受准直器选择的影响。
Purpose of this study was to assess the impact of mediastinal region of interest (ROI) definition on intra- and inter-observer variability in relation to collimator type.Thirty-five subjects with CHF (80% men, mean age 66 +/- A 9 years, NYHA 2.4 +/- A 0.5, LVEF 29 +/- A 8.4%) were enrolled. 15 minutes and 4 hours post-injection (p.i.) of I-123-MIBG, planar images were sequentially acquired with low energy high energy (LEHR) and medium energy (ME) collimators. In the first analysis, observer-defined mediastinal ROI was used. In the second analysis, a predefined mediastinal ROI was used. Intra- and inter-observer variability of late H/M was assessed using Lin's concordance coefficient (LCC).There was substantial agreement between all three observers using predefined mediastinum ROI. LCCs for LEHR were 0.98, 0.96, and 0.95, for ME 0.98, 0.97, and 0.97. However, observer-defined mediastinal ROI resulted in poor-moderate agreement. LCCs for LEHR were 0.82, 0.94, and 0.70, for ME 0.77, 0.91, and 0.80. Intra-observer analysis using predefined mediastinal ROI showed substantial agreement. LCC was 0.97 for LEHR and 0.96 for ME.Predefined mediastinal ROI results in low intra- and inter-observer variability of late H/M and is, therefore, to be preferred over observer-defined mediastinal ROI. Intra- and inter-observer variability of late H/M is not influenced by collimator choice.