INTESTINAL-ABSORPTION AND SECRETION OF OCHRATOXIN-A IN THE RAT
INTESTINAL-ABSORPTION AND SECRETION OF OCHRATOXIN-A IN THE RAT
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DOI：
10.1016/0041-008x(82)90326-x
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发表时间：
1982-01-01
影响因子：
3.8
通讯作者：
AIBARA, K
中科院分区：
文献类型：
--
作者：
KUMAGAI, S;AIBARA, K
研究了大鼠胃肠道对赭曲霉毒素A（OA）的吸收和分泌。当OA被引入到胃肠道的各个部位的管腔中时，在毒素被注入到空肠近端的管腔中之后，门静脉血中OA的浓度最大。在空肠近端封闭袢内注射OA后，OA在肠系膜静脉血浆中的出现率高于淋巴液。静脉血浆中的出现率随着OA管腔浓度的增加而增加;在淋巴中，该速率相对于OA管腔浓度几乎保持恒定。最大吸收部位为近端空肠，主要吸收途径为门静脉，但在给予低剂量OA时，不能排除淋巴途径的作用。当静脉注射OA后灌注胃肠道的各个部分时，肠灌注液中出现了明显量的毒素，表明肠分泌可能是OA的另一种排泄途径。肠分泌和吸收的比较表明，OA在肠粘膜中的不对称转移，管腔到血液的转移大于相反方向的转移。
The absorption and secretion of ochratoxin A (OA) by the gastrointestinal tract was studied in the rat. When OA was introduced into the lumen at various sites of the gastrointestinal tract, the largest concentration of OA in portal blood was found after the toxin was injected into the lumen at the proximal jejunum. After injection of OA into a closed loop at the proximal jejunum, the rate of appearance of OA in the mesenteric venous plasma was higher than that in lymph. The rate of appearance in the venous plasma increased with an increased luminal concentration of OA; in the lymph the rate remained almost constant with respect to the luminal OA concentration. The site of maximal absorption was the proximal jejunum and the primary route of absorption was the portal vein although the contribution of the lymphatic route could not be excluded when low-dose levels of OA were given. When various parts of the gastrointestinal tract were perfused after i.v. injection of OA, noticeable amounts of the toxin appeared in the intestinal perfusate, suggesting that intestinal secretion may have been another route of excretion of OA. Comparison of intestinal secretion and absorption showed asymmetric transfer of OA across the intestinal mucosa, the lumen-to-blood transfer being greater than that in the opposite direction.