Antiviral activities of Artemisia princeps var. orientalis essential oil and its α-thujone against norovirus surrogates
Antiviral activities of Artemisia princeps var. orientalis essential oil and its α-thujone against norovirus surrogates
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DOI：
10.1007/s10068-017-0158-3
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发表时间：
2017-10-01
影响因子：
2.9
通讯作者：
Chung, Mi Sook
中科院分区：
文献类型：
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作者：
Chung, Mi Sook
蒿属植物侧柏是一种著名的药用食品，已用于治疗包括细菌感染在内的多种疾病。我们检查了 A. Princeps var. 精油的抗病毒作用。侧柏及其化合物、冰片、α-侧柏酮和樟脑，可对抗鼠诺如病毒-1 (MNV-1) 和猫杯状病毒-F9 (FCV-F9)。添加时间斑块测定用于确定精油干扰病毒感染的能力。在FCV-F9和MNV-1预处理后，在0.1%和0.01%的精油下，FCV-F9和MNV-1的最大活性分别达到48%的抑制和64%的抑制。冰片和樟脑均未表现出抗病毒活性，而精油的主要化合物 α-侧柏酮对 FCV-F9 和 MNV-1 表现出强烈的抑制作用。
Artemisia princeps var. orientalis is a well-known medicinal food, which has been used for the treatment of several diseases including bacterial infection. We examined the antiviral effects of the essential oil from A. princeps var. orientalis and its compounds, borneol, alpha-thujone and camphor, against murine norovirus-1 (MNV-1) and feline calicivirus-F9 (FCV-F9). The time-of-addition plaque assays were used to determine the ability of essential oil to interfere with viral infection. The maximum activities, following the pretreatment of FCV-F9 and MNV-1, reached 48% inhibition on FCV-F9 and 64% inhibition on MNV-1 at 0.1 and 0.01% of the essential oil, respectively. Neither borneol nor camphor exhibited an antiviral activity, whereas alpha-thujone, a major compound of the essential oil, showed strong inhibition on FCV-F9 and MNV-1.