Andropause and psychopathology: minor symptoms rather than pathological ones
Andropause and psychopathology: minor symptoms rather than pathological ones
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DOI：
10.1016/s0306-4530(02)00102-6
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发表时间：
2003-10-01
影响因子：
3.7
通讯作者：
Legros, JJ
中科院分区：
文献类型：
--
作者：
Delhez, M;Hansenne, M;Legros, JJ
本研究考察了诊断为男性更年期的男性的心理症状，以及计算的游离睾酮(T)与抑郁情绪、焦虑和生活质量之间的关系。研究对象是153名年龄在50-70岁之间的男性，他们参加了男性更年期的筛查。测定总睾酮、FSH、LH和SHBG水平。抑郁情绪用卡罗尔评定量表评估，焦虑用一般健康问卷的“焦虑-失眠”维度评估，生活质量用世界卫生组织生活质量问卷评估。结果表明，游离T水平随年龄增长而下降，而FSH和LH水平随年龄增长而增加。性腺功能低下的受试者的卡罗尔评定量表得分较高，但平均得分较低，并非病态。卡罗尔量表评估的抑郁严重程度与游离T水平呈负相关。然而，在这个量表上得分显著的受试者与抑郁得分不显著的受试者相比，并没有表现出不同的游离T水平。焦虑和生活质量在性腺功能低下和性腺功能正常的受试者之间没有差异。因此，目前的研究表明，男性更年期并不以特定的心理症状为特征，但可能与不被认为是病理性的“抑郁症状”有关。2003爱思唯尔科学有限公司版权所有。
This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects were 153 men, aged 50-70 years, who participated in a screening of andropause. Total testosterone, FSH, LH and SHBG levels were measured. Depressed mood was assessed with the Carroll Rating Scale, anxiety with the "anxiety-insomnia" dimension of the General Health Questionnaire, and quality of life with the World Health Organisation Quality of Life questionnaire. The results showed that levels of free T decreased with age, whereas FSH and LH increased. Carroll Rating Scale scores were higher among hypogonadal subjects, but the mean score was low and not pathological. A negative correlation was observed between severity of depression as assessed by the Carroll Rating Scale and free T levels. However, subjects with a significant score on this scale did not exhibit different free T levels compared to subjects with a non-significant depressive score. Anxiety and quality of life did not differ between hypogonadal and eugonadal subjects. The present study therefore suggests that andropause is not characterised by specific psychological symptoms, but may be associated with "depressive symptoms" that are not considered as pathological. (C) 2003 Elsevier Science Ltd. All rights reserved.