Day to day changes in free and total PSA: significance of biological variation
Day to day changes in free and total PSA: significance of biological variation
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DOI：
10.1038/sj.pcan.4500212
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发表时间：
1997-12-01
影响因子：
4.8
通讯作者：
Brawer, MK
中科院分区：
文献类型：
--
作者：
Nixon, RG;Wener, MH;Brawer, MK
在这项研究中，我们评估了游离和总前列腺特异性抗原（PSA）水平的生理变化，以确定游离/总PSA百分比如何受到影响。24名患者连续10个工作日抽血。计算生物学变异的变异系数百分比（% CV）。结果呈对数正态分布，游离PSA、总PSA和游离/总PSA百分比的几何平均值分别为12.0% CV、7.3% CV和8.8% CV。当应用时，游离/总PSA百分比需要波动31%，以表明显著变化（临界差异，P
In this study we evaluated the physiological variation of free and total prostate-specific antigen (PSA) levels to determine how the percent free/total PSA was affected. Twenty four patients had blood drawn for ten consecutive weekdays. The percent coefficient of variation (% CV) of biological variation was calculated. The results were log-normally distributed with geometric means of 12.0% CV, 7.3% CV, and 8.8% CV for free, total, and percent free/total PSA, respectively. When applied, the percent free/total, PSA would need to fluctuate by 31% to indicate that a significant change (critical difference, P