Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings
Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings
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DOI：
10.1155/2016/4343514
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Sandoughi, Mahnaz
中科院分区：
文献类型：
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作者：
Jafari, Seyyed Mehdi;Salimi, Saeedeh;Sandoughi, Mahnaz
瞄准！本研究旨在评价系统性红斑狼疮（SLE）患者的促氧化-抗氧化平衡（PAB）及其与实验室检查和临床表现的关系。方法.在这项病例对照研究中，60例SLE患者和60名健康人入选。采集血样，分离血清。随后，使用PAB测定法评价每个样品的促氧化剂-抗氧化剂平衡值。结果SLE患者的PAB平均值显著高于健康对照组（147.3 ± 42 vs 84.8 ± 32.2 HK，P < 0.0001）。SLE患者PAB与血沉（ESR）呈显著正相关（r = 0.492，P < 0.001）。此外，脱发、盘状皮疹、口腔溃疡、关节炎和肾炎患者的PAB值显著高于无这些表现的患者。结论本研究结果表明，SLE患者PAB均值明显增高，PAB与ESR呈正相关。此外，在伴有脱发、盘状皮疹、口腔溃疡、关节炎和肾炎的SLE患者中发现PAB升高。这些结果表明，PAB的测量可能是有用的，以显示氧化应激状态的SLE患者。
Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147.3 +/- 42 versus 84.8 +/- 32.2 HK, P < 0.0001). Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) (r = 0.492, P < 0.001). In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations. Conclusion. The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR. Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis. These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients.