Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases.
Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases.
复制标题
DOI：
10.1111/j.1527-3466.2004.tb00148.x
复制
发表时间：
2006-06
期刊：
影响因子：
--
通讯作者：
Wei Zhou;H. Chai;P. Lin;A. Lumsden;Q. Yao;Changyi J. Chen
中科院分区：
文献类型：
--
作者：
Wei Zhou;H. Chai;P. Lin;A. Lumsden;Q. Yao;Changyi J. Chen
银杏是现存最古老的树种之一，被誉为活化石。银杏叶提取物 (GBE) 是最常用的草药之一，因其所谓的滋补作用以及可能的治疗和恢复特性而广受欢迎。越来越多的证据表明 GBE 在治疗心血管疾病方面具有潜在作用。我们研究了 GBE 的使用历史，并回顾了有关其对心血管系统影响的文献。在涉及细胞培养和动物模型的广泛研究中，GBE 已被证明通过多种机制发挥其作用。据报道，GBE 具有抗氧化特性，可以改变血管舒缩功能，减少血细胞与内皮的粘附，抑制血小板和平滑肌细胞的活化，影响离子通道，并改变信号转导。此外，CBE的相关临床试验正在进行中，特别是在治疗动静脉功能不全以及预防血栓形成方面。最后，讨论了有争议的临床结果以及 GBE 与其他药物之间可能存在的不良相互作用。这篇综述强调了银杏叶在心血管疾病中的潜在益处，强调了我们当前研究的差距，并表明有必要对 CBE 的心血管特性进行更严格的系统研究。
Ginkgo biloba is one of the oldest living tree species that has been referred to as a living fossil. Extract from Ginkgo biloba leaves (GBE) is among the most commonly used herbal drugs and is popularized for its alleged tonic effect and possible curative and restorative properties. There is an increasing evidence of the potential role of GBE in treating cardiovascular diseases. We examined the history of GBE usage and reviewed the literature on its effects on the cardiovascular system. In the extensive studies involving cell cultures and animal models, GBE has been shown to exert its action through diverse mechanisms. GBE has been reported to have antioxidatant properties, to modify vasomotor function, to reduce adhesion of blood cells to endothelium, to inhibit activation of platelets and smooth muscle cells, to affect ion channels, and to alter signal transduction. In addition, relevant clinical trials with CBE are being carried out, particularly in the treatment of arterial and venous insufficiency and in the prevention of thrombosis. Finally, the controversial clinical findings and the possible adverse interactions between GBE and other drugs are discussed. This review underscores the potential benefits of Ginkgo biloba in cardiovascular diseases, highlights the gaps in our current research, and suggests the necessity for more rigorous systematic investigation of cardiovascular properties of CBE.