Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey in England
Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey in England
复制标题
DOI：
10.1192/bjp.bp.110.083642
复制
发表时间：
2011-07-01
影响因子：
10.5
通讯作者：
Jenkins, Rachel
中科院分区：
文献类型：
--
作者：
Bebbington, Paul;Jonas, Sarah;Jenkins, Rachel
研究背景一系列样本中的一些研究证实儿童期性虐待和精神病之间存在联系。目的使用具有代表性的大样本(成人精神病学发病率调查2007)的数据来检验儿童期性虐待与精神病有关的假设，并且这种关系与再受害经历、大量吸食大麻、焦虑和抑郁的调解是一致的。结果16岁以前的性虐待与精神病密切相关，尤其是涉及非双方同意的性行为(优势比(OR)=10.14，95%可信区间4.8~21.3，人群归因风险分数14%)。有证据表明焦虑和抑郁起到了部分调节作用，但成年后没有大量吸食大麻或再次受害。结论儿童期性虐待与精神病之间有很大的联系，而且可能是有原因的。这些结果对精神病的本质和病因、治疗和一级预防具有重要的意义。
BackgroundA number of studies in a range of samples attest a link between childhood sexual abuse and psychosis.AimsTo use data from a large representative general population sample (Adult Psychiatric Morbidity Survey 2007) to test hypotheses that childhood sexual abuse is linked to psychosis, and that the relationship is consistent with mediation by revictimisation experiences, heavy cannabis use, anxiety and depression.MethodThe prevalence of psychosis was established operationally in a representative cross-sectional survey of the adult household populat on of England (n = 7353). Using computer-assisted self-interview, a history of various forms of sexual abuse was established, along with the date of first abuse.ResultsSexual abuse before the age of 16 was strongly associated with psychosis, particularly if it involved non-consensual sexual intercourse (odds ratio (OR) = 10.14, 95% CI 4.8-21.3, population attributable risk fraction 14%). There was evidence of partial mediation by anxiety and depression, but not by heavy cannabis use nor revictimisation in adulthood.ConclusionsThe association between childhood sexual abuse and psychosis was large, and may be causal. These results have important implications for the nature and aetiology of psychosis, for its treatment and for primary prevention.