Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides
Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides
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DOI：
10.1080/15257770701501492
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发表时间：
2007-01-01
影响因子：
1.3
通讯作者：
Agrofoglio, Luigi A.
中科院分区：
文献类型：
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作者：
Broggi, Julie;Joubert, Nicolas;Agrofoglio, Luigi A.
我们在此比较了三种铜 (I) 催化剂通过微波（和热）辅助 Huisgen 1,3-偶极环加成合成各种 1,4-二取代-1,2,3-三唑并碳核苷的范围。本研究选择了六氟磷酸四(乙腈)铜([Cu(CH3CN4]PF6)、咪唑啉(甲基)溴化铜(Imes)CuBr和铜/硫酸铜Cu(0)/CuSO4(II)混合物。根据炔烃取代基、溶剂或加热方法分析它们对催化量的影响。
We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acelonitrile)copper hexafluorophosphate ([Cu(CH3CN4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method.