Cannibalism by sporulating bacteria
Cannibalism by sporulating bacteria
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DOI：
10.1126/science.1086462
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发表时间：
2003-07-25
期刊：
影响因子：
56.9
通讯作者：
Losick, R
中科院分区：
文献类型：
--
作者：
Gonzalez-Pastor, JE;Hobbs, EC;Losick, R
枯草芽孢杆菌孢子的形成是一个复杂的发育过程，是由营养限制触发的。在这里，我们报道了进入产孢途径的细胞产生并输出一种杀伤因子和一种信号蛋白，它们协同作用以阻止姐妹细胞产孢并导致它们裂解。产孢细胞以由此释放的营养物质为食，这使它们能够继续生长，而不是完成形态发生。我们认为，产孢是一种最后的应激反应途径，枯草芽孢杆菌通过蚕食其兄弟姐妹来推迟孢子形成的承诺。
Spore formation by the bacterium Bacillus subtilis is an elaborate developmental process that is triggered by nutrient limitation. Here we report that cells that have entered the pathway to sporulate produce and export a killing factor and a signaling protein that act cooperatively to block sister cells from sporulating and to cause them to lyse. The sporulating cells feed on the nutrients thereby released, which allows them to keep growing rather than to complete morphogenesis. We propose that sporulation is a stress-response pathway of last resort and that B. subtilis delays a commitment to spore formation by cannibalizing its siblings.