Ventricular Enlargement in Schizophrenia
Ventricular Enlargement in Schizophrenia
复制标题
精神分裂症的心室扩大
DOI：
10.1192/bjp.147.3.233
复制
发表时间：
1985
影响因子：
10.5
通讯作者：
M. Reveley
中科院分区：
文献类型：
--
作者：
M. Reveley
总结在使用计算机断层扫描（CT）的研究中，精神分裂症患者和对照组的心室扩大的患病率和心室大小的值都有相当大的范围。采用线性、平面和半自动计算机化方法，对19例无血缘关系的慢性精神分裂症患者（均为单卵双生子）和36例年龄性别匹配的正常双生子（18对单卵双生子）进行了CT扫描。所有的方法区分精神分裂症患者与对照组在大约相同的显着性水平，但部分容积伪影导致一个大于两倍的变化，明显的心室大小，并显着降低了有效性和可靠性的机械平面和线性措施。在使用这些技术的非对照研究中，测量误差可能是伪影的一个重要来源，并且在比较研究之间的绝对值时，但是使用计算机化方法应该显著减少伪影的这种来源，并允许更有意义的比较。
Summary There has been a considerable range in both the prevalence of ventricular enlargement and values for ventricular size of both schizophrenics and controls, in studies using computerised tomography (CT). The CT scans of 19 unrelated chronic schizophrenics, all of monozygotic (MZ) twin birth, and 36 age-and-sex-matched normal twins from 18 MZ pairs were examined by linear, planimetric, and semi-automated computerised methods. All methods distinguished schizophrenics from controls at approximately the same level of significance, but partial volume artefact led to a greater than two-fold variation in apparent ventricular size, and significantly reduced the validity and reliability of mechanical planimetric and linear measures. Measurement error may be an important source of artefact in uncontrolled studies using those techniques, and when comparing absolute values across studies, but the use of computerised methods should significantly reduce this source of artefact and allow more meaningful comparison.