Interstrand cross-link of DNA by covalently linking a pair of abasic sites
Interstrand cross-link of DNA by covalently linking a pair of abasic sites
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DOI：
10.1039/c2cc16785a
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Komatsu, Yasuo
中科院分区：
文献类型：
--
作者：
Ichikawa, Kohei;Kojima, Naoshi;Komatsu, Yasuo
DNA中形成的一对脱嘌呤/脱嘧啶中心与双(氨氧基)衍生物共价连接。链间交联剂的作用与两个氨氧基的结构连接有关。链间交联构建了稳定的DNA支架，用于酶的比对。
A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment.