Serotonin and emotional processing: Does it help explain antidepressant drug action?
Serotonin and emotional processing: Does it help explain antidepressant drug action?
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DOI：
10.1016/j.neuropharm.2008.06.036
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Harmer, Catherine J.
中科院分区：
文献类型：
--
作者：
Harmer, Catherine J.
人们越来越关注抗抑郁药物治疗对情绪处理措施的影响。这些行动可能有助于我们了解单胺在抑郁症情绪功能障碍中的作用，以及抗抑郁药物治疗如何起作用。最近的研究表明，色氨酸耗竭导致的中枢5-羟色胺功能下降可以恢复恢复抑郁症患者的负偏差，即使剂量不足以引起情绪变化。相反，在健康志愿者和急性抑郁症患者的治疗早期，抗抑郁药物的给药增加了积极情绪信息的处理。这种积极偏见的增加可能为随后的认知重建和学习提供了一个平台，这有助于抑郁症症状变化的演变。功能性神经影像学研究表明，这些早期的抗抑郁作用涉及额边缘和纹状体外回路，提示对情感刺激的初始评价和注意力处理的作用。因此，这种方法可以提供一个框架，将情绪障碍的心理和生物过程与其治疗联系起来。抗抑郁药可能不会直接调节情绪和焦虑，而是允许我们对自我，世界和未来进行不同的评估。(C)2008爱思唯尔有限公司保留所有权利。
There is growing interest in the effects of antidepressant drug treatment on measures of emotional processing. Such actions may help us understand the role of monoamines in emotional dysfunction in depression and how antidepressant drug treatments work. Recent studies suggest that decreasing central serotonin function with tryptophan depletion can reinstate negative biases in recovered depressed patients, even at doses insufficient to induce changes in mood. Conversely, antidepressant drug administration increases the processing of positive emotional information in healthy Volunteers and acutely depressed patients early in treatment. This increase in positive bias may provide a platform for subsequent cognitive restructuring and learning which contributes to the evolution of symptom change in depression. Functional neuroimaging studies suggest that these early antidepressant effects involve fronto-limbic and extra-striate circuitry suggestive of actions on both the initial appraisal and attentional processing of affective stimuli. This approach may therefore provide a framework for linking psychological and biological processes in emotional disorders and their treatment. Antidepressants may not directly modulate mood and anxiety but rather allow a different perspective for our ongoing evaluation Of Our self, the world and the future. (C) 2008 Elsevier Ltd. All rights reserved.