Modulation of lectin-triggered superoxide release from neutrophils of tumor patients with and without chemotherapy.
Modulation of lectin-triggered superoxide release from neutrophils of tumor patients with and without chemotherapy.
复制标题
调节凝集素触发的肿瘤患者中性粒细胞释放的超氧化物，无论是否接受化疗。
作者：
A. V. Timoshenko;K. Kayser;P. Drings;G. Kolb;K. Havemann;H. Gabius
中性粒细胞产生的超氧化物被认为有助于宿主防御系统的效率。这种活性受到甘露糖特异性凝集素伴刀豆球蛋白A、N-乙酰葡糖胺/神经氨酸特异性小麦胚芽凝集素和来自槲寄生和人胎盘的半乳糖苷特异性凝集素的刺激。为了评估这方面的免疫功能是否受到影响的癌症患者没有或与治疗，中性粒细胞制剂从69名患者进行了检查。减少O2。在与伴刀豆球蛋白A和人凝集素孵育后，观察到支气管癌患者的（-）-产生，而来自乳腺癌患者的样品在没有或有治疗的情况下，在存在四种凝集素中的每一种的情况下，没有表现出显著改变的活性。肺癌和结直肠癌患者的化疗降低了对刀豆球蛋白A和槲寄生凝集素的嗜酸性反应。与来自其他癌症类型和造血系统恶性肿瘤的9份标本相似，没有普遍的反应性损害。除了凝集素的性质外，当试图增强宿主防御系统对抗感染和恶性细胞的这一因素时，还应考虑到个体间的巨大差异。
Superoxide production by neutrophils is believed to contribute to the efficiency of the host defence system. This activity is stimulated by the mannose-specific lectin concanavalin A, the N-acetylglucosamine/neuraminic acid-specific wheat germ agglutinin and the galactoside-specific lectins from Viscum album and human placenta. To assess whether this aspect of immune function is affected in cancer patients without or with treatment, neutrophil preparations from 69 patients were examined. Reductions in O2.(-)-production were observed for bronchial carcinoma patients after incubation with concanavalin A and the human lectin, while samples from breast cancer patients without or with treatment exhibited no significantly altered activity in the presence of each of the four agglutinins. Chemotherapy of lung and colorectal carcinoma patients reduced the neutrophilic response to concanavalin A and Viscum album agglutinin. As similarly shown for 9 specimens from other carcinoma types and from hemopoietic malignancies, there is no general impairment of responsiveness. In addition to the property of the lectin, the large extent of interindividual variation should be taken into account when it is attempted to enhance this factor of the host defence system against infections and malignant cells.