Genomic control of patterning
Genomic control of patterning
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DOI：
10.1387/ijdb.072495ip
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发表时间：
2009-01-01
影响因子：
0.7
通讯作者：
Davidson, Eric H.
中科院分区：
文献类型：
--
作者：
Peter, Isabelle S.;Davidson, Eric H.
多细胞生物体的发展涉及将有机体划分为具有特定结构和功能的细胞区域。空间构图过程的信息直接编码在基因组中。基因组通过构成基因调控网络(GRN)的相互作用，根据阶段和位置决定自己的用途。GRN驱动海胆胚胎内胚层发育的不同调控策略说明了启动、协调、稳定或排除发育程序以确定发育中特定区域的模式的不同调控策略。
The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome. The genome determines its own usage depending on stage and position, by means of interactions that constitute gene regulatory networks (GRNs). The GRN driving endomesoderm development in sea urchin embryos illustrates different regulatory strategies by which developmental programs are initiated, orchestrated, stabilized or excluded to define the pattern of specified territories in the developing embryo.