Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial
Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial
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DOI：
10.1186/s12931-020-01466-1
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发表时间：
2020-08-17
影响因子：
5.8
通讯作者：
Sohrabi, Zahra
中科院分区：
文献类型：
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作者：
Ahmadi, Afsane;Eftekhari, Mohammad Hassan;Sohrabi, Zahra
背景：为慢性阻塞性肺疾病（COPD）患者开发有效的营养支持仍然具有挑战性。本研究的目的是探讨每日食用强化乳清对炎症，肌肉质量，功能和生活质量的影响，在中度至重度COPD.Methods患者：一个单盲，随机试验研究进行COPD患者（n = 46）。干预组（n = 23）每天接受250 ml镁和维生素C强化乳清饮料，持续8周。炎症细胞因子（包括白细胞介素-6（IL-6）和肿瘤坏死因子（TNF α））的任何变化是主要结局，次要结局是去脂体重、握力、营养不良、谷胱甘肽和丙二醛血清浓度以及健康相关生活质量（HRQoL）。分别采用生物电阻抗分析法和液压握力计测量身体成分和肌肉力量。结果：共纳入44例患者。与对照组相比，干预组的IL-6浓度显著降低。此外，FFMI，身体蛋白质和握力在干预组中显着增加，两组之间的显着变化。此外，与对照组相比，干预组的健康相关生活质量有所改善。其他研究变量无显著变化。结论：这种新型的营养干预降低了炎症细胞因子水平，改善了骨骼肌质量和肌肉力量指数，并最终增加了中重度COPD患者的HRQoL。因此，建议进一步研究营养干预对COPD进展的影响。
Background: The development of effective nutritional supports for patients with chronic obstructive pulmonary diseases (COPD) is still challenging. This study was conducted to investigate the efficacy of daily consumption of fortified whey on inflammation, muscle mass, functionality, and quality of life in patients with moderate-to-severe COPD.Methods: A single-blind, randomized trial study was performed on patients with COPD (n = 46). Participants in the intervention group (n = 23) daily received 250 ml of whey beverage fortified with magnesium and vitamin C for 8 weeks. Any changes in inflammatory cytokines (including interleukin- 6 (IL-6) and tumor necrosis factor (TNF alpha)) were the primary outcomes and the secondary outcomes were fat-free mass, handgrip strength, malnutrition, glutathione and malondialdehyde serum concentrations, and health-related quality of life (HRQoL). Body composition and muscle strength were measured by Bioelectrical Impedance Analysis (BIA) and hydraulic hand dynamometer, respectively. Fat-free mass index (FFMI) was also calculated.Results: At the end of the study, 44 patients were analyzed. There were significant decreases in IL-6 concentrations in the intervention group compared to the control group. Also, FFMI, body protein, and handgrip strength increased significantly in the intervention group with significant changes between two groups. Moreover, improvement in health-related quality of life was observed in the intervention group compared to the control group. There were no significant changes in other study variables.Conclusions: This novel nutritional intervention decreased inflammatory cytokines levels, improved indices of skeletal muscle mass and muscle strength, and ultimately, increased HRQoL in patients with moderate-to-severe COPD. Thus, it is suggested to do further studies to assess the effects of nutrition intervention on COPD progression.